淫羊藿苷治疗骨质疏松症的研究进展

中华养生保健 ›› 2023, Vol. 41 ›› Issue (4): 58-62.

淫羊藿苷治疗骨质疏松症的研究进展

朱元超¹, 秦浩添², 刘苏², 陈奕孝¹, 张耕¹, 廖帅², 翁鉴², 于斐², 曾晖^1,*

1.遵义医科大学研究生院,贵州遵义, 563000;
2.北京大学深圳医院骨关节科,广东深圳, 518036

出版日期:2023-02-16 发布日期:2023-02-16
通讯作者: ^*曾晖,E-mail：zenghui@pkuszh.com。
作者简介:朱元超（1995—）,男,汉族,籍贯：贵州省安顺市,硕士研究生在读,医师,研究方向：骨关节疾病与骨愈合。
基金资助:
国家自然科学基金（82172432,82102568,82001319）; 骨科生物材料国家地方联合工程研究中心（XMHT20190204007）; 深圳市高水平医院建设专项经费资助：高水平“登峰学科建设”（SZXK023）; 深圳“医疗卫生三名工程”项目（SZSM201612092）; 深圳市科技研发资金项目（Z2021N054,JCYJ20210324110214040）; 广东省基础与应用基础研究基金（2021A1515012586）; 白求恩·石药骨质疏松科研基金项目（G-X-2020-1107-21）; 北京大学深圳医院科研启动金项目（KYQD2021099）

Research Progress of Icariin in the Treatment of Osteoporosis

ZHU Yuan-chao¹, QIN Hao-tian², LIU Su², CHEN Yi-xiao¹, ZHANG Geng¹, LIAO Shuai², WENG Jian², YU Fei², ZENG Hui^1,*

1. Graduate school, Zunyi Medical University, Zunyi Guizhou, 563000, China;
2. Department of Bone and Joint, Peking University Shenzhen Hospital, Shenzhen Guangdong, 518036, China

Online:2023-02-16 Published:2023-02-16

摘要/Abstract

摘要： 骨质疏松症是以骨量减少、骨组织结构损害为特征的慢性疾病,在中老年人群中（尤其在绝经后女性人群中）发病率较高。该病严重威胁患者身心健康,给患者家庭带来沉重负担。临床治疗骨质疏松的西药因不良反应多和价格昂贵等影响了其应用。淫羊藿作为我国传统中药,使用安全、容易获取,被广泛应用于骨科疾病的治疗。前期研究证实,淫羊藿的主要成分淫羊藿苷在治疗骨质疏松症中有良好应用前景,其可通过上调成骨标志物碱性磷酸酶（ALP）、RUNX2、BMP-2等的表达促进成骨细胞、骨髓间充质干细胞（BMSCs）的增殖分化作用,并实现骨再生及骨形成,在这一过程中Wnt/β-catenin、OPG/RANK/RANKL等信号通路发挥重要作用。基于此,本文对淫羊藿苷治疗骨质疏松症的作用及可能机制作一综述。

关键词: 淫羊藿苷, 骨质疏松症, 成骨标志物, Wnt/β-catenin信号通路, OPG/RANK/RANKL信号通路

Abstract: Osteoporosis is a chronic disease characterized by bone loss and structural damage of bone tissue. It has a high incidence rate in middle-aged and elderly people, especially in postmenopausal women. The disease seriously threatens the physical and mental health of patients and brings heavy burden to their families. Because of its side effects and high price, the use of drugs for the treatment of osteoporosis has been affected. Epimedium, a traditional Chinese medicine, is safe to use and easy to obtain. It is widely used in the treatment of orthopedic diseases. Previous studies have confirmed that icariin, the main component of epimedium, has a good application prospect in the treatment of osteoporosis. It can promote the proliferation and differentiation of osteoblasts and BMSCs by up regulating the expression of osteogenic markers ALP, RUNX2, BMP-2, etc., and achieve bone regeneration and bone formation. In this process, Wnt/ β- Catenin, OPG/RANK/RANKL and other signaling pathways play an important role. Based on this, this article reviews the effect and possible mechanism of icariin on osteoporosis.

Key words: icariin, osteoporosis, osteogenic markers, Wnt/β-catenin signaling pathway, OPG/RANK/RANKL signaling pathway

中图分类号:

朱元超, 秦浩添, 刘苏, 陈奕孝, 张耕, 廖帅, 翁鉴, 于斐, 曾晖. 淫羊藿苷治疗骨质疏松症的研究进展[J]. 中华养生保健, 2023, 41(4): 58-62.

ZHU Yuan-chao, QIN Hao-tian, LIU Su, CHEN Yi-xiao, ZHANG Geng, LIAO Shuai, WENG Jian, YU Fei, ZENG Hui. Research Progress of Icariin in the Treatment of Osteoporosis[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(4): 58-62.

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