柴胡加龙牡汤对乳腺增生患者的疗效及血清性激素水平的影响

摘要/Abstract

摘要： 目的探讨与分析柴胡加龙牡汤对乳腺增生患者的疗效及血清性激素水平的影响。方法选择2019年2月—2021年7月在新疆生产建设兵团第六师总医院诊治的86例乳腺增生患者作为研究对象,根据随机数表法将患者分为中医组与对照组,各43例。对照组给予甲基睾丸素治疗,中医组在对照组治疗的基础上给予柴胡加龙牡汤治疗,治疗观察4周,判定治疗效果与检测性激素水平变化情况。结果治疗后中医组的总有效率与对照组相比有明显提高,但差异无统计学意义（P>0.05）。治疗后两组乳房肿块评分与乳房疼痛评分都明显低于治疗前（P<0.05）,治疗后中医组的乳房肿块评分与乳房疼痛明显低于对照组（P<0.05）。治疗后两组血清泌乳素（PRL）、睾酮（T）水平都显著低于治疗前（P<0.05）,治疗后中医组的血清PRL、T含量明显低于对照组（P<0.05）。中医组治疗期间的恶心、眩晕、月经失调、胃肠道反应等不良反应发生率与对照组相比稍有降低,但差异无统计学意义（P>0.05）。结论柴胡加龙牡汤治疗乳腺增生能提高总有效率,减少不良反应的发生,还可降低患者的血清PRL、T水平,持续改善患者的临床症状。

关键词: 柴胡加龙牡汤, 乳腺增生, 不良反应, 泌乳素, 睾酮, 性激素

Abstract: Objective To explore and analysis the curative effect of Chaihu Jialongmu Decoction on breast hyperplasia patients and its effect on serum sex hormone levels. Methods From February 2019 to July 2021, 86 cases of patients with breast hyperplasia who were diagnosed and treated in Xinjiang Production and Construction Corps Sixth Division General Hospital were selected as the research objects. Accorded to the principle of random number table method, the patients were divided into the traditional Chinese medicine group and the control group with 43 cases in each groups. The control group were given methyl testosterone treatment, and the traditional Chinese medicine group were given Chaihu Jialongmu Decoction treatment on the basis of the treatment of the control group. Results After treatment, the total effective rate in the traditional Chinese medicine group was significantly higher than that in the control group, but the differencewas not statistically significant (P>0.05). The breast lump scores and breast pain scores in two groups after treatment were significantly lower than those before treatment (P<0.05), and the breast lump scores and breast pain scores of traditional Chinese medicine group were also significantly lower than that in the control group after treatment (P<0.05). The levels of serum prolactin (PRL) and testosterone (T) in both groups after treatment were significantly lower than those before treatment (P<0.05), and the traditional Chinese medicine group were also significantly lower than that in the control group after treatment (P<0.05). The incidence of adverse reactions such as nausea, vertigo, menstrual disorders and gastrointestinal reactions during treatment in the traditional Chinese medicine group was slightly lower than that in the control group, there was no statistical significance in the incidence of adverse reactions between two groups (P>0.05). Conclusion Chaihu Jialongmu Decoction in the treatment of breast hyperplasia can improve the total effective rate of patients, reduce the occurrence of adverse reactions, and also reduce the serum PRL and T levels of patients, promote the continuous improvement of clinical symptoms of patients.

Key words: Chaihu Jialongmu Decoction, breast hyperplasia, adverse reactions, prolactin, testosterone, sex hormones

中图分类号:

王建军. 柴胡加龙牡汤对乳腺增生患者的疗效及血清性激素水平的影响[J]. 中华养生保健, 2023, 41(4): 26-29.

WANG Jian-jun. Effect of Chai Hu Jia Long Mu Decoction on Patients with Hyperplasia of Mammary Glands and Serum Sex Hormone Levels[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(4): 26-29.

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