清气化痰汤加减疗法联合布地奈德对慢阻肺急性加重期患者的疗效观察

摘要/Abstract

摘要： 目的研究清气化痰汤加减疗法联合布地奈德对慢阻肺急性加重期的疗效。方法选择2020年9月—2022年12月民乐县人民医院收治的316例慢阻肺急性加重期患者为研究对象,按随机数表法分为对照组和观察组,每组158例。对照组雾化吸入布地奈德,观察组在对照组基础上联用清气化痰汤加减疗法。检测两组的第1秒用力呼气容积/用力肺活量（FEV₁/FVC）、最大肺活量（VCmax）、最大自主通气量（MVV）和FEV₁%预期值;气道平台压（Pplat）、气道阻力（Raw）和气道峰压（PIP）;血清白细胞介素-8（IL-8）、单核细胞趋化蛋白1（MCP -1）和肿瘤坏死因子-α（TNF-α）水平。结果治疗后,观察组临床有效率明显高于对照组（P<0.05）;两组的FEV₁/FVC、VCmax、MVV和FEV₁%预期值均明显升高（P<0.05）,且观察组明显高于对照组（P<0.05）;两组Pplat、Raw和PIP均明显改善（P<0.05）,且观察组明显优于对照组（P<0.05）;两组的血清IL-8、MCP -1和TNF-α水平均明显降低（P<0.05）,且观察组低于对照组（P<0.05）。结论清气化痰汤加减疗法联合布地奈德对慢阻肺急性加重期患者有显著的疗效,能明显改善呼吸力学水平和肺功能,减轻炎症反应。

关键词: 清气化痰汤加减疗法, 布地奈德, 急性加重期, 慢阻肺

Abstract: Objective To investigate the effect of Qingqi Huatan Decoction plus budesonide on patients with acute exacerbation of chronic obstructive pulmonary disease. Methods Selected 316 cases of patients with acute exacerbation of chronic obstructive pulmonary disease from September 2020 to December 2022, divided into two groups randomly. The control group was inhaled budesonide by atomization, and the observation group was treated with Qingqi Huatan Decoction. The 1s forced expiratory volume/forced vital capacity (FEV₁/FVC), maximum vital capacity (VCmax), maximum voluntary ventilation volume (MVV) and FEV₁% of the two groups were measured; Airway platform pressure (Pplat), airway resistance (Raw) and airway peak pressure (PIP); Serum interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-α (TNF-α). Results After treatment, the effective rate of the observation group was significantly higher than control group (P<0.05). the expected values of FEV₁/FVC, VCmax, MVV and FEV₁% in the two groups were significantly higher (P<0.05), and the expected values in the observation group were significantly higher than those in the control group (P<0.05). The Pplat, Raw and PIP of the two groups were significantly improved (P<0.05), and the observation group were significantly better than those of the control group (P<0.05). The serum levels of IL-8, MCP-1 and TNF-α in both groups were significantly decreased (P<0.05), the observation group was lower (P<0.05). Conclusion Qingqi Huatan Decoction plus budesonide has a significant effect on acute exacerbation of chronic obstructive pulmonary disease, which can significantly improve the level of respiratory mechanics and lung function, and reduce inflammatory reaction.

Key words: Qingqi Huatan Decoction plus or minus therapy, budesonide, acute exacerbation period, chronic obstructive pulmonary disease

中图分类号:

R259

写国斌. 清气化痰汤加减疗法联合布地奈德对慢阻肺急性加重期患者的疗效观察[J]. 中华养生保健, 2023, 41(16): 36-40.

XIE Guo-bin. Observation on the Curative Effect of Qingqi Huatan Decoction Plus Budesonide on Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(16): 36-40.

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