胸腺五肽与常规抗结核方案联合治疗对肺结核患者免疫应答及肺功能的影响

摘要/Abstract

摘要： 目的分析胸腺五肽联合常规抗结核方案在肺结核患者中的效果。方法回顾性分析2021年4月—2022年4月日照市结核病防治所收治的80例肺结核患者病历有关资料,按治疗方法不同分为对照组和观察组,每组40例。对照组患者采用常规抗结核方案（2HRZE/4HR）治疗,观察组患者采用胸腺五肽联合常规抗结核方案治疗。对比两组痰菌转阴率、病灶吸收率、免疫功能、肺功能、不良反应。结果观察组治疗2个月、治疗8个月后的痰菌转阴率与病灶明显吸收率高于对照组,差异具有统计学意义（P<0.05）;治疗前,两组CD3⁺、CD4⁺、CD8⁺与用力肺活量（FVC）、第1秒用力呼吸容积（FEV₁）、呼气流量峰值（PEF）相比,差异无统计学意义（P>0.05）;治疗后,观察组CD3⁺、CD4⁺、FVC、FEV₁、PEF高于对照组,CD8⁺低于对照组,差异有统计学意义（P<0.05）;两组不良反应发生率比较,差异无统计学意义（P>0.05）。结论胸腺五肽+常规抗结核方案在肺结核患者中作用明显,可加快其痰菌转阴,促进病灶吸收,明显改善其免疫功能与肺功能,且无严重不良反应,临床应用价值较高,值得临床应用。

关键词: 肺结核, 胸腺五肽, 抗结核治疗, 免疫功能

Abstract: Objective To analyze the effect of thymus pentapeptide combined with conventional antituberculosis regimen in patients with pulmonary tuberculosis. Methods The medical records of 80 tuberculosis patients diagnosed and treated by Rizhao Tuberculosis Prevention and Control Institute from April 2021 to April 2022 were retrospectively analyzed and divided into two groups according to different treatment methods. Among them, 40 patients treated with conventional anti-tuberculosis regimen (2HRZE/4HR) were included in the control group, and 40 patients treated with thymus pentapeptide combined with conventional anti-tuberculosis regimen were included in the observation group. Sputum negative conversion rate, focus absorption rate, immune function, lung function and adverse reactions were compared between the two groups. Results After 2 months and 8 months of treatment, the sputum negative conversion rate and obvious focus absorption rate in the observation group were higher than those in the control group, with statistical differences (P<0.05). Before treatment, CD3⁺, CD4⁺ and CD8⁺ had no statistical differences in forced vital capacity (FVC), forced breathing volume at the first second (FEV₁) and peak expiratory flow (PEF) between the two groups (P>0.05). After treatment, CD3⁺, CD4⁺, FVC, FEV₁ and PEF in the observation group were higher than those in the control group, while CD8⁺ was lower than those in the control group, with statistical difference (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Thymus pentapeptide and conventional anti-tuberculosis regimen has an obvious effect in patients with pulmonary tuberculosis, which can accelerate sputum negative conversion, promote lesion absorption, and significantly improve immune function and lung function without serious adverse reactions. Therefore, it has high clinical application value and is worthy of vigorous implementation.

Key words: tuberculosis, thymus pentapeptide, antituberculosis therapy, immune function

中图分类号:

R521

纪铜镇. 胸腺五肽与常规抗结核方案联合治疗对肺结核患者免疫应答及肺功能的影响[J]. 中华养生保健, 2023, 41(16): 15-18.

JI Tong-zhen. Effect of Thymus Pentapeptide Combined with Routine Antituberculosis Regimen on Immune Response and Lung Function in Patients with Pulmonary Tuberculosis[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(16): 15-18.

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