奕韵本草饮辅助改善卵巢功能临床研究

中华养生保健 ›› 2023, Vol. 41 ›› Issue (16): 1-4.

• 论著 • 下一篇

奕韵本草饮辅助改善卵巢功能临床研究

寇秋爱¹, 夏立营¹, 王文乾^2,*, 杨家熙², 孙文婷¹, 张颖³, 袁景泉³, 杨宜婷³

1.中国中医科学院西苑医院中医药保健研究中心,北京,100091;
2.北京中医药大学临床医学院,北京,100029;
3.无限极（中国）有限公司,广东广州,510405

出版日期:2023-08-16 发布日期:2023-08-08
通讯作者: ^*王文乾,E-mail：wqdmail0011@163.com。
作者简介:寇秋爱（1964—）,女,汉族,籍贯：北京市,硕士研究生,主任医师,研究方向：中医药保健产品研究。

Clinical Study on Yiyun Materia Medica Yin in Auxiliary Improving Ovarian Function

KOU Qiu-ai¹, XIA Li-ying¹, WANG Wen qian^2,*, YANG Jia-xi², SUN Wen-ting¹, Zhang Ying³, YUAN Jing-quan³, YANG Yi-ting³

1. Health Care Research Center of Traditional Chinese Medicine,Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, 100091, China;
2. Clinical School of Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China;
3. Infinitus (China) Co., LTD, Guangzhou Guangdong, 510405, China

Online:2023-08-16 Published:2023-08-08

摘要/Abstract

摘要： 目的评价奕韵本草饮对卵巢储备功能的辅助改善作用,为治疗卵巢储备功能减退提供新途径。方法选取2020年8月—2021年4月中国中医科学院西苑医院招募的64例卵巢储备功能减退者作为研究对象,根据入组顺序将受试者分为试验组与对照组,每组32例,观察周期均为12周,比较两组受试者试食前后性激素水平、双侧窦卵泡数（AFC）、抗缪勒管激素（AMH）、性生活指标、月经指标以及症状体征积分的变化。结果试食前,两组受试者FSH、AFC、AMH、性生活指标、月经指标及症状体征积分比较,差异无统计学意义（P>0.05）,均衡性良好;试食后,试验组FSH较前减低,AFC、AMH及性生活指标、症状体征积分均较试食前有所改善,其中试验组试食后FSH、性生活指标及症状体征积分较对照组改善明显, 差异有统计学意义（P<0.05）。结论奕韵本草饮对卵巢储备功能减退有一定的辅助改善作用,而且安全性良好。

关键词: 卵巢储备功能下降, 奕韵本草饮, 临床研究

Abstract: Objective To evaluate the auxiliary effect of Yiyun Materia Medica Yin in improving the ovarian reserve, so as to provide a way for early treatment of DOR. Methods A total of 64 subjects with diminished ovarian reserve who were recruited were enrolled in this study from August 2020 to April 2021.They were assigned to two groups: the experimental group and the control group, according to the sequence, with 32 cases in each group. The trail continued twelve weeks. After the trail,the sex hormone levels, number of bilateral sinus follicles, sexual life indicators, menstrual indicators and symptom and sign scores of the two groups of subjects were compared between the two groups before and after treatment. Result Before the trail, there was no significant difference in all indicators between the two groups(P>0.05). After the trail, the FSH in the experimental group was lower than before, and the scores of AFC, AMH, sexual life indicators, symptoms and signs were improved compared with at the begining of the trail. The FSH, sexual life indicators, symptoms and signs were significantly different from those in the control group after the trail (P<0.05). Conclusion Yiyun Materia Medica Yin can effectively improve the decreased ovarian reserve, and the safety is good.

Key words: decreased ovarian reserve, Yiyun Materia Medica Yin, clinical research

中图分类号:

R271

寇秋爱, 夏立营, 王文乾, 杨家熙, 孙文婷, 张颖, 袁景泉, 杨宜婷. 奕韵本草饮辅助改善卵巢功能临床研究[J]. 中华养生保健, 2023, 41(16): 1-4.

KOU Qiu-ai, XIA Li-ying, WANG Wen qian, YANG Jia-xi, SUN Wen-ting, Zhang Ying, YUAN Jing-quan, YANG Yi-ting. Clinical Study on Yiyun Materia Medica Yin in Auxiliary Improving Ovarian Function[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(16): 1-4.

参考文献

[1] 卵巢储备功能减退临床诊治专家共识[J].生殖医学杂志,2022,31(4):425-434.
[2] TACHIBANA M, KUNO T, YAEGASHI N.Mitochondrial replacement therapy and assisted reproductive technology:a paradigm shift toward treatment of genetic diseases in gametes or in early embryos[J]. Reprod Med Biol,2018,17(4):421-433.
[3] KRISTENSEN S G, PORS S E, ANDERSEN C Y.Improving oocyte quality by transfer of autologous mitochondria from fully grown oocytes[J].Hum Reprod,2017,32(4):725-732.
[4] YU R, JIN H, HUANG X, et al.Comparison of modified agonist, mild-stimulation and antagonist protocols for in vitro fertilization in patients with diminished ovarian reserve[J]. J Int Med Res,2018,46(6):2327-2337.
[5] 安东,刘丽敏.补肾类中成药治疗卵巢储备功能下降的Meta分析[J].中国老年学杂志,2021,41(20):4425-4431.
[6] WEI M, MAHADY G B, LIU D, et al.Astragalin, a Flavonoid from Morus alba (Mulberry) Increases Endogenous Estrogen and Progesterone by Inhibiting Ovarian Granulosa Cell Apoptosis in an Aged Rat Model of Menopause[J]. Molecules,2016,21(5):675.
[7] 蔡妙婷,刘雯,袁源见,等.覆盆子中几种黄酮类成分活性研究进展[J].实用中西医结合临床,2020,20(4):179-182.
[8] 王金金,毋启桐,时博,等.小茴香炮制历史沿革、化学成分及药理作用研究进展[J].中国实验方剂学杂志,2020,26(20):178-190.
[9] 曹泽毅. 中华妇产科学(第3版)(下册)[M].北京:人民卫生出版社,2014:4382-4387.
[10] 杨文文,杨琪,崔楠,等.补肾法治疗卵巢储备功能下降随机对照研究文献的系统评价[J].中国中医基础医学杂志,2021,27(6):978-985.
[11] 熊仪,马文君,霍少川,等.补肾调癸方治疗卵巢储备功能减退的临床研究[J].广州中医药大学学报,2022,39(6):1300-1305.
[12] 向罗珺,金子涵,申玉华,等.补肾调周法治疗肾虚血瘀型卵巢储备功能下降的临床观察[J].实用内科学志,2022,36(8):103-106.
[13] 李善霞,何东云,张艳红,等.补肾养血方治疗肾阴虚型卵巢储备功能下降的临床观察[J].中华中医药学刊,2019,37(2):361-364.
[14] 国家药典委员会.中华人民共和国药典[M].一部.北京:中国医药科技出版社,2020:313.
[15] 刘莹,覃骊兰,蓝毓营.桑葚化学成分、药理作用及质量标志物研究进展[J].重庆医学,2021,50(6):1063-1067.
[16] 黄长盛,贺守第,管雁丞,等.菟丝子黄酮和槲皮素对雷公藤多苷致卵巢早衰大鼠卵巢功能的影响[J].中国临床药理学杂志,2020,36(6):667-670.
[17] 曹圣,热增才旦,李永平,等.覆盆子益精理论的转化应用[J].转化医学电子杂志,2018,5(5):52-55.
[18] LUNDING S A, AKSGLAEDE L, ANDERSON R A, et al.AMH as predictor of premature ovarian insufficiency:A longitudinal study of 120 Turner Syndrome patients[J]. J Clin Endocrinol Metab, 2015, 100(7):E1030-1038.

奕韵本草饮辅助改善卵巢功能临床研究

Clinical Study on Yiyun Materia Medica Yin in Auxiliary Improving Ovarian Function

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