藏药“佐太”的研究进展

中华养生保健 ›› 2023, Vol. 41 ›› Issue (10): 64-67.

藏药“佐太”的研究进展

邓城旗^1,2,3,4,5, 洛松罗布^5,6, 尹毅青^1,2,3,4, 郑向前^1,2,3,4,5,*

1.天津医科大学肿瘤医院麻醉科,天津,300060;
2.国家恶性肿瘤临床医学研究中心,天津,300060;
3.天津市恶性肿瘤临床医学研究中心,天津,300060;
4.天津市肿瘤防治重点实验室,天津,300060;
5.昌都市藏医院手术室,西藏昌都,854085;
6.昌都藏药厂质量部,西藏昌都,854085

出版日期:2023-05-16 发布日期:2023-05-16
通讯作者: ^*郑向前,E-mail：xiangqian_zheng@163.com。
作者简介:邓城旗（1986—）,男,汉族,籍贯：山西省晋城市,硕士研究生,副主任医师,研究方向：麻醉与认知、疼痛研究。
基金资助:
天津麻醉科研发展计划项目（TJMZ2022-010）; 天津市医学重点学科（专科）建设项目（TJYXZDXK-009A）

Research Progress of the Tibetan Medicine “Zuotai”

DENG Cheng-qi^1,2,3,4,5, Luobu Luosong^5,6, YIN Yi-qing^1,2,3,4, ZHENG Xiang-qian^1,2,3,4,5,*

1. Department of Anesthesiology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China;
2. National Clinical Research Center for Cancer, Tianjin, 300060, China;
3. Tianjin’s Clinical Research Center for Cancer, Tianjin, 300060,China;
4. Key laboratory of Cancer Prevention and Therapy,Tianjin, 300060,China;
5. Operating Room, Changdu Tibetan Medical Hospital, Changdu Xizang, 854085,China;
6. Quality Department, Changdu Tibetan Medicine Factory, Changdu Xizang, 854085, China

Online:2023-05-16 Published:2023-05-16

摘要/Abstract

摘要： 藏医药是我国重要的传统医学。“佐太”是藏药中最具代表性的炮制品,是用来配制多种珍宝类藏药制剂的主要原料之一,在藏药体系中发挥着重大作用。由于“佐太”成分复杂,含有诸多重金属物质,在现代医学临床的应用和推广受到一定的限制。本研究对近年来有关“佐太”的化学成分、作用机制研究、安全性研究、应用研究进行综述,旨在为“佐太”进一步的研究提供参考。

关键词: 藏药, 佐太, 化学成分, 作用机制, 安全性研究, 应用研究

Abstract: Tibetan medicine is an important traditional medicine in China. "Zuotai" is the most representative concoction in Tibetan medicine, which is one of the main raw materials used to formulate many kinds of precious Tibetan medicine preparations and plays a significant role in the Tibetan medicine system. Because of its complex composition and the presence of many heavy metals, the application and promotion of "Zuotai" in modern medical clinics are somewhat restricted. In this paper, we review the chemical composition, mechanism of action, safety and application of "Zuotai" in recent years, with the aim of providing reference for further research on “Zuotai”.

Key words: Tibetan medicine, Zuotai, chemical composition, mechanism of action, safety study, application study

中图分类号:

R614

邓城旗, 洛松罗布, 尹毅青, 郑向前. 藏药“佐太”的研究进展[J]. 中华养生保健, 2023, 41(10): 64-67.

DENG Cheng-qi, Luobu Luosong, YIN Yi-qing, ZHENG Xiang-qian. Research Progress of the Tibetan Medicine “Zuotai”[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(10): 64-67.

参考文献

[1] LUO H.Traditional Tibetan medicine in China: an overview of current status and prospects[J]. Chin J Integr Med,2015,21(1):67-70.
[2] 宇妥·元丹贡布.四部医典[M].江苏科学技术出版社,2016:2-14.
[3] 干泓侠,冯楠,李远飞,等.藏药佐太的粉末X射线衍射指纹图谱及微观结构形态研究[J].中草药,2022,53(11):3321-3328.
[4] 热增才旦,热毛先,周加本,等.佐太及其主要辅料中无机元素分析[J].中成药,2021,43(5):1253-1258.
[5] 索南昂秀. 略谈藏医药佐太的炮制及应用[J].中国民族医药杂志,2018,24(1):35-36.
[6] 周自强,孙芳云.藏药“佐太”的研究进展[J].中国民族民间医药,2020,29(23):55-59.
[7] HUANG H B, WANG Q Z, WANG X W, et al.Overview of current researches on Tibetan medicine "zuotai"[J]. Zhongguo Zhong Yao Za Zhi,2013,38(17):2886-2888.
[8] LIU J, ZHANG F, RAVIKANTH V, et al.Chemical Compositions of Metals in Bhasmas and Tibetan Zuotai Are a Major Determinant of Their Therapeutic Effects and Toxicity[J]. Evid Based Complement Alternat Med,2019,10:1697804.
[9] 杨梦,周雪姣,李向阳.藏药佐太的研究现状与进展[J].药学研究,2016,35(11):663-667.
[10] 张婷,贾雯靖,岳会兰,等.佐太对柔红霉素的增效作用[J].中成药,2021,43(9):2500-2504.
[11] 张婷,贾雯靖,岳会兰,等.藏药佐太起效形式研究[J].青海科技,2021,28(1):47-50,60.
[12] 杨梦,年永琼,周雪姣,等.藏药佐太对药物代谢酶CYP2C11和CYP2D1的活性及蛋白和mRNA表达的影响[J].中国高原医学与生物学杂志,2017,38(3):176-182,205.
[13] 范雪汝,朱俊博,姚星辰,等.藏药佐太对大鼠CYP1A2和NAT2活性的影响[J].中国药房,2015,26(28):3932-3934.
[14] NIE Y, XU S F, LU Y L, et al.Zuotai (β-HgS)-containing 70 Wei Zhen-Zhu-Wan differs from mercury chloride and methylmercury on hepatic cytochrome P450 in mice[J]. F1000Res,2021,10:203.
[15] ZHANG B B, XU S F, XU Y S, et al.Effect of Zuotai and HgS on gene expression of drug-metabolizing enzymes in livers of mice[J]. Zhongguo Zhong Yao Za Zhi,2017,42(21):4195-4200.
[16] LI C, XU W, CHU S, et al.The chemical speciation, spatial distribution and toxicity of mercury from Tibetan medicine Zuotai,β-HgS and HgCl2 in mouse kidney[J]. J Trace Elem Med Biol,2018,45:104-113.
[17] 向丽,林波,张艳,等.藏药“佐太”长期用药对大鼠肾脏Kim-1、MT及相应mRNA表达水平的影响[J].中药药理与临床,2014,30(6):154-158.
[18] 向丽,曾勇,林波,等.藏药“佐太”长期给药对大鼠肾脏潜在氧化损伤的初步研究[J].中药与临床,2015,6(3):39-42.
[19] ZHOU L L, CHEN H J, HE Q Q, et al.Evaluation of hepatotoxicity potential of a potent traditional Tibetan medicine Zuotai[J]. J Ethnopharmacol,2019,234:112-118.
[20] 张炜,刘海青,骆桂法,等.佐太及珍宝类藏成药中汞在大鼠体内的蓄积研究[J].中国药事,2020,34(2):195-201.
[21] 赵静,杜玉枝,魏立新,等.藏药佐太中汞在小鼠体内的蓄积[J].中成药,2017,39(7):1351-1355.
[22] LI C, WANG D P, DUO J, et al.Study on safety of Tibetan medicine zuotai and preliminary study on clinical safety of its compound dangzuo[J].Zhongguo Zhong Yao Za Zhi,2014,39(13):2573-2582.
[23] 杨红霞,于明杰,斗周才让,等.当佐与安置精华散对人体肝肾功能的影响[J].华西药学杂志,2016,31(5):548-551.
[24] SALLON S, DORY Y, BARGHOUTHY Y,et al.Is mercury in Tibetan Medicine toxic? Clinical, neurocognitive and biochemical results of an initial cross-sectional study[J]. Experimental Biology and Medicine,2017,242(3):316-332.
[25] XIA Z, WEI L, DU Y, et al.Effect of the Tibetan Medicine Zuotai on Degranulation and Inflammatory Mediator Release in RBL-2H3 Cells[J]. Chem Pharm Bull (Tokyo),2018,66(8):818-821.
[26] 朱婷,沈蓓,王新为,等.藏药“佐太”通过抑制caspase-3促进293细胞增殖[J].中国民族医药杂志,2013,19(5):47-49.
[27] LI H, LI WK, LU Y F, et al.The Tibetan medicine Zuotai influences clock gene expression in the liver of mice[J]. PeerJ,2016,4:e1632.
[28] 耿卢婧,李岑,夏政华,等.佐太、β-HgS、HgCl2对PC12细胞活性和凋亡相关基因表达影响的比较[J].中成药,2019,41(3):543-548.
[29] 夏政华,李岑,毕宏涛,等.藏药佐太和甲基汞对神经细胞Neuro-2a毒性的差异比较[J].甘肃农业大学学报,2021,56(1):29-36.
[30] ZHENG Z Y, LI C, ZHANG M, et al.Dissolution, absorption and bioaccumulation in gastrointestinal tract of mercury in HgS-containing traditional medicines Cinnabar and Zuotai[J]. Zhongguo Zhong Yao Za Zhi,2015,40(12):2455-2460.
[31] 张明,毕宏涛,李岑,等.藏药佐太在模拟胃液、肠液中的汞溶出差异[J].中成药,2018,40(10):2302-2304.
[32] ZHENG Z, ZHANG M, XIAO Y, et al.Effect of Cys, GSH, and pH on Mercury Release from Tibetan Medicine Zuotai, β-HgS, and α-HgS in Artificial Gastrointestinal Juices[J]. Biol Trace Elem Res,2018,184(2):536-545.
[33] 李雁,王晓喜,毕宏涛,等.藏药当佐对功能性消化不良大鼠胃肠激素水平的影响[J].中成药,2020,42(9):2472-2475.
[34] 杨桑加,多杰措.含汞当佐和不含汞安置精华散治疗胃病的疗效与安全性研究[J].中西医结合心血管病电子杂志,2018,6(20):173.
[35] 斗周才让,仁增加,李先加.含重金属藏成药当佐治疗胃病的疗效与安全性研究[J].中华中医药杂志,2021,36(9):5701-5704.
[36] NIE Y, ZHANG B, HUANG B, et al.Protective efects of 70 Wei Zhen-Zhu-Wan against carbon tetrachloride induced liver injury in mice[J]. Journal of Zunyi Medical University,2017,40(4):358-363.
[37] LI Q, LI H J, XU T, et al.Natural Medicines Used in the Traditional Tibetan Medical System for the Treatment of Liver Diseases[J]. Front Pharmacol,2018,9:29.
[38] 赵静,张明,耿卢婧,等.藏药佐太在两种抑郁小鼠模型中的抗抑郁活性[J].中成药,2016,38(7):1461-1467.
[39] 牛翠英,赵静,耿卢婧,等.佐太对慢性束缚应激抑郁模型小鼠的行为学影响[J].中药药理与临床,2016,32(6):179-183.
[40] ZHAO J, NIU C, WANG J, et al.The depressive-like behaviors of chronic unpredictable mild stress-treated mice, ameliorated by Tibetan medicine Zuotai: involvement in the hypothalamic-pituitary-adrenal (HPA) axis pathway[J]. Neuropsychiatr Dis Treat,2018,14:129-141.
[41] 杨红霞,李梦园,袁发荣,等.经典藏药佐太对15种人源肿瘤细胞系的体外增殖抑制研究[J].青海科技,2022,29(4):115-129.