银杏叶提取物注射液治疗急性脑梗死的疗效评价

摘要/Abstract

摘要： 目的探究急性脑梗死患者应用银杏叶提取物注射液治疗的效果和价值。方法抽取2020年3月~2021年5月烟台市莱阳中心医院神经内科收治的42例急性脑梗死患者,根据随机数表法分为观察组和对照组,每组21例。对照组患者给予醒脑静注射液,观察组患者在对照组治疗基础上加用银杏叶提取物注射液,观察两组患者的疗效、治疗前后患者脑功能缺损评分、日常活动量评分;脑梗死体积、细胞因子水平;神经功能因子及血清炎症因子水平等指标改善情况。结果观察组患者的疗效明显优于对照组,差异有统计学意义（P<0.05）。治疗后,观察组患者NIHSS及ADL评分均优于对照组,差异有统计学意义（P<0.05）。与对照组比较,观察组患者脑梗死体积较小且基质金属蛋白酶-9（MMP-9）、B型脑钠肽（BNP）及血清胱抑素C（Cys-C）水平较低,差异有统计学意义（P<0.05）。与对照组比较,观察组患者血清炎症因子白细胞介素（IL）-6、IL-8及C反应蛋白（CRP）水平较低,差异有统计学意义（P<0.05）。与对照组比较,观察组患者胶质纤维酸性蛋白（GFAP）、神经元特异性烯醇化酶（NSE）及 S-100B 蛋白等神经功能因子水平较低,差异有统计学意义（P<0.05）。结论银杏叶提取物注射液治疗急性脑梗死效果显著,可提高临床疗效并改善患者预后。

关键词: 急性脑梗死, 银杏叶提取物注射液, 醒脑静注射液, 脑功能缺损

Abstract: Objective To explore the efficacy and value of Ginkgo biloba extract injection for patients with acute cerebral infarction. Methods 42 patients with acute cerebral infarction were selected from the Department of Neurology, Laiyang Central Hospital, Yantai City. The research started in March,2020 and finished in May,2021. All cases were divided into 2 groups according to the random number table(21 cases in each group). The control group was treated with additional Xingnaojing injection, and the observation group was treated with Ginkgo biloba extract injection. The therapeutic effect, brain function impairment, daily activity, cerebral infarction volume, cytokine level, nerve function factor and serum inflammatory factor were observed before and after treatment. Results Analysis of treatment efficacy: the observation group was as high as 95.24%, and the control group was only 66.67%. (P<0.05). After treatment, the observation group had milder brain function deficits, better daily activities, smaller cerebral infarction volume, and lower serum inflammatory factors and neurological function factors than those of control group. Data comparison between the two groups was catistically significant (P<0.05). Conclusion Ginkgo biloba extract injection has a significant effect on the treatment of acute cerebral infarction, which can improve the clinical efficacy and improve the prognosis of patients.

Key words: acute cerebral infarction, Ginkgo biloba extract injection, Xingnaojing injection, brain function defect

中图分类号:

R971

陈永清. 银杏叶提取物注射液治疗急性脑梗死的疗效评价[J]. 中华养生保健, 2022, 40(7): 4-6.

CHEN Yong-qing. Evaluation of Ginkgo Biloba Extract Injection in the Treatment of Acute Cerebral Infarction[J]. ZHONGHUA YANGSHENG BAOJIAN, 2022, 40(7): 4-6.

参考文献

[1] 张玉松,杨劲松,李洁儿.银杏叶提取物联合依达拉奉治疗急性脑梗死的疗效及对患者血清炎症因子的影响[J].海南医学,2019, 30(12):1507-1509.
[2] 何其胜,王龙海,王爱萍.银杏叶提取物联合小牛血清去蛋白注射液治疗急性脑梗死的临床研究[J].中西医结合心脑血管病杂志,2019,17(17):2679-2682.
[3] 饶明俐,王文志,黄如训.中国脑血管病防治指南[M].北京:人民卫生出版社,2007:365.
[4] 崔丽娟,焦富英.正压通气联合银杏叶提取物对急性脑梗死合并阻塞性睡眠呼吸暂停综合征患者脑血流动力学及血液流变学的影响[J].现代中西医结合杂志,2017,26(32):3538-3541,3628.
[5] 阿布都沙拉木·阿布都热衣木,居来提·艾买提,木胡牙提.醒脑静注射液联合银杏叶提取物注射液治疗老年急性脑梗死的临床研究[J].中国临床药理学杂志,2018,34(11):1282-1284.
[6] 董维森,孙志毅,李洁,等.银杏叶提取物与三七总皂苷辅助治疗急性脑梗死临床疗效及安全性的Meta分析[J].实用心脑肺血管病杂志,2017,25(3):1-5.
[7] 方蒡,毛琴,李晓飞,等.银杏叶提取物联合阿托伐他汀对老年脑梗死患者疗效和血清炎症介质水平的影响[J].辽宁中医杂志,2018, 45(2):319-321.
[8] 王斯玥,高海亮,张聪,等.基于系统评价的银杏叶片治疗高血压病、脑梗死、冠心病心绞痛药物经济学分析[J].世界中西医结合杂志, 2019,14(4):473-480.
[9] 李曼,潘东,刘丙营.银杏叶提取物联合尤瑞克林促进急性脑梗死后血管再生及认知功能改善的效果观察[J].山西医药杂志,2017, 6(30):691-694.
[10] 张宣宣,王卫东,王靖秋,等.银杏叶提取物注射液对老年2型糖尿病患者并发脑梗死事件的一级预防作用[J].中国临床保健杂志, 2018,21(1):18-21.
[11] 李春雷,张峰.醒脑静注射液联合银杏叶提取物注射液对老年急性脑梗死病人MMP-9、BNP及Cys-C的影响[J].中西医结合心脑血管病杂志,2017,15(12):1435-1438.
[12] 卢军栋,苏鹏,王峥,等.注射用丹参多酚酸对急性脑梗死的疗效及对患者血清NSE及S-100β蛋白的影响[J].药物评价研究,2019, 42(2):283-286.
[13] 薛成莲,刘力楠,马剡芳.银杏叶提取物注射液联合阿替普酶静脉溶栓对急性脑梗死神经功能及血清MCP-1、GFAP水平的影响[J].临床和实验医学杂志,2019,18(10):1045-1049.
[14] 邢英瀛,齐献忠,张小林.丁苯酞软胶囊联合银杏叶提取物注射液治疗急性脑梗死的临床效果观察[J].中国民康医学,2019,31(1):101-103.
[15] 常新,王瑞丽,郭建松,等.银杏叶提取物联合醒脑静注射液治疗急性脑梗死的临床效果[J].临床医学研究与实践,2019,4(9):122-124.