阿替普酶联合丁苯酞改善脑梗死患者脑血管储备功能及血流动力学的作用研究

摘要/Abstract

摘要： 目的研究阿替普酶联合丁苯酞改善脑梗死患者脑血管储备功能及血流动力学的作用。方法选取2019年5月~2021年5月烟台市莱阳中心医院收治的108例脑梗死患者作为研究对象,全体患者入院后均采取控制血脂、血压、神经营养、清除自由基等常规治疗方法,根据随机数表法进行分组,每组54例。参照组患者在常规治疗基础上运用阿替普酶药物进行溶栓,研讨组患者则采取阿替普酶联合丁苯酞药物进行溶栓,主要就其脑血管储备功能及血流动力学的作用进行研究分析。结果治疗后,研讨组患者脑血管储备功能指标值高于参照组,研讨组患者梗死区平均脑血流量、平均脑血流速等血流动力学指标高于参照组,而特性阻抗、脑血管阻力指标则低于参照组,研讨组患者神经功能缺损程度低于参照组,而日常生活活动能力水平则高于参照组,差异均有统计学意义（P<0.05）。结论阿替普酶联合丁苯酞改善脑梗死患者脑血管储备功能及血流动力学的作用明显,有效减轻患者氧化应激损伤,有利于神经功能改善与日常生活能力提升,此治疗方案具备可行性。

关键词: 阿替普酶, 丁苯酞, 脑梗死, 脑血管储备功能, 血流动力学, 作用研究

Abstract: Objective To study the effect of alteplase combined with butylphthalide on cerebral vascular reserve function and hemodynamics in patients with cerebral infarction. Methods 108 patients with cerebral infarction admitted to Laiyang Central Hospital from May 2019 to May 2021 were selected as the study objects. After admission, all patients were divided into groups according to random number table method. Both groups were given routine treatments, such as blood lipid, blood pressure control, neuronutrition, free radical elimination, etc. Each group included 54 cases. In the control group, the patients were treated with antithrombotic regimen of alteplase and the patients in the study group were treated with antithrombotic regimen of alteplase combined with butylphthalide. The purpose of this study was to investigate the cerebral vascular reserve function and the role of hemodynamics. Results After treatments, the indexes of cerebrovascular reserve function in the study group were higher than those in the control group, and the indexes of mean cerebral blood flow and mean cerebral blood flow velocity in the infarcted area in the study group were higher than those in the Hemodynamics group, the indexes of specific impedance and cerebral vascular resistance were lower in the study group than those in the control group, the degree of neurological impairment in the study group was lower than that in the control group, and the level of activities of daily living （Adl） was higher than that in the control group （P<0.05）. Conclusion Alteplase combined with butylphthalide can significantly improve the cerebral vascular reserve function and hemodynamics function in patients with cerebral infarction. It can effectively alleviate the oxidative stress injury of patients, and is beneficial to the improvement of neurological function and the improvement of the ability of daily living, with feasible treatment.

Key words: alteplase, butylphthalide, cerebral infarction, cerebrovascular reserve function, hemodynamics, function research

中图分类号:

R743

陈永清. 阿替普酶联合丁苯酞改善脑梗死患者脑血管储备功能及血流动力学的作用研究[J]. 中华养生保健, 2022, 40(5): 4-7.

CHEN Yong-qing. Effect of Alteplase Combined with Butylphthalide on Cerebrovascular Reserve Function and Hemodynamics in Patients with Cerebral Infarction[J]. ZHONGHUA YANGSHENG BAOJIAN, 2022, 40(5): 4-7.

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