达克罗宁胶浆联合氟比洛芬酯预防男性全麻腔镜碎石术后导尿管所致膀胱刺激症状的效果

中华养生保健 ›› 2022, Vol. 40 ›› Issue (24): 45-48.

达克罗宁胶浆联合氟比洛芬酯预防男性全麻腔镜碎石术后导尿管所致膀胱刺激症状的效果

胡斌, 徐振海^*, 刘冰, 赵浩延, 陈学玲

徐州市中医院泌尿外科,江苏徐州,221000

出版日期:2022-12-16 发布日期:2022-12-16
通讯作者: ^*徐振海,E-mail：55144445@qq.com。
作者简介:胡斌（1983.8-）,男,汉族,籍贯：江苏省徐州市,硕士研究生,副主任医师,研究方向：泌尿外科。
基金资助:
江苏省中医药科技发展计划项目（YB2020048）

Effectiveness of Dyclonine Hydrochloride Mucilage Combined with Flurbiprofen Axetil for Prevention Catheter-Related Bladder Discomfort Caused by Urinary Tube Stimulation in Male Patients after General Anesthesia Endoscopic Lithotripsy

HU Bin, XU Zhen-hai^*, LIU Bing, ZHAO Hao-yan, CHEN Xue-ling

Urology Surgery, Xuzhou Hospital Affiliated to Nanjing University of Chinese Medicine, Xuzhou Jiangsu, 221000, China

Online:2022-12-16 Published:2022-12-16

摘要/Abstract

摘要： 目的探讨达克罗宁胶浆联合氟比洛芬酯在预防男性全麻腔镜碎石术后导尿管所致膀胱刺激症状的临床疗效。方法选取2020年1月~2021年12月徐州市中医院收治的男性上尿路结石患者80例,采用随机数表法将患者分为四组：A组为达克罗宁胶浆组,B组为氟比洛芬酯组,C组为达克罗宁胶浆联合氟比洛芬酯组,D组为对照组,每组20例。碎石手术结束,导尿前A组和C组向尿道内注入达克罗宁胶浆3 mL,并用达克罗宁胶浆涂抹润滑导尿管行导尿术,B组和D组使用水性润滑剂涂抹润滑导尿管行导尿术。返回病房后B组和C组立即给予0.9%氯化钠溶液100 mL+氟比洛芬酯50 mg静脉滴注,A组和D组给予0.9%氯化钠溶液100 mL静脉滴注。将全麻苏醒喉罩拔除至尿管拔除期间分为三个时间段,喉罩拔除至返回病房时间段为T1,返回病房至完全清醒时间段为T2,完全清醒至尿管拔除时间段为T3。观察每组患者不同阶段导尿相关躁动发生情况,并采用疼痛数字评分法（NRS）评价不同时间段的疼痛程度。结果 C组在T1的躁动率低于B和D组（P<0.05）,与A组比较差异无统计学意义（P>0.05）;C组在T2的躁动率低于A和D组（P<0.05）,与B组比较差异无统计学意义（P>0.05）;四组在T3的尿管相关躁动发生率对比差异无统计学意义（P>0.05）,同时,随着时间的延长,各组的躁动率逐渐降低（P<0.05）。C组在T1的NRS评分低于B和D组（P<0.05）,与A组比较差异无统计学意义（P>0.05）;C组在T2的NRS评分低于A和D组（P<0.05）,与B组比较差异无统计学意义（P>0.05）;C组在T3的NRS评分低于A组（P<0.05）,与B和D组比较差异无统计学意义（P>0.05）;同时,随着时间的延长,B、C组的NRS评分逐渐降低（P<0.05）。结论达克罗宁胶浆联合氟比洛芬酯在男性全麻腔镜碎石术后应用可明显持续减轻导尿管所致膀胱刺激症状、缓解疼痛,效果优于单药使用,值得临床应用。

关键词: 达克罗宁胶浆, 氟比洛芬酯, 导尿管相关膀胱刺激征

Abstract: Objective To investigate the clinical efficacy of dyclonine hydrochloride mucilage combined with flurbiprofen axetil in the prevention of catheter-induced bladder irritation symptoms in men after general anesthesia endoscopic lithotripsy. Methods A total of 80 male patients with upper urinary tract stones admitted to our urology department from January 2020 to December 2021 were selected and divided into four groups using the randomized numerical table method. Group A was the dyclonine hydrochloride mucilage group. Group B was the flurbiprofen axetil group. Group C was the dyclonine hydrochloride mucilage combined with flurbiprofen Axetil group, and group D was the control group, with 20 cases in each group. After lithotripsy, before catheterization, groups A and C injected 3 mL of dyclonine hydrochloride mucilage into the urethra and used dyclonine hydrochloride mucilage to lubricate the catheter for catheterization, while groups B and D used aqueous lubricant to lubricate the catheter for catheterization. Following return to the ward, groups B and C were immediately given 0.9% NaCl solution 100 mL + flurbiprofen axetil 50 mg IV, and groups A and D were given 0.9% NaCl solution 100 mL IV. The period between the removal of the laryngeal mask for general anesthesia awakening and the removal of the urinary catheter was divided into three time periods. The time period from mask removal to ward return was T1, the time period from ward return to full wakefulness was T2, and the time period from full wakefulness to urethral catheter removal was T3. The occurrence of catheterization-related agitation at different stages was observed in each group, and the pain level at different time periods was evaluated using the pain numerical rating scale (NRS). Results The agitation rate of group C at T1 time was lower than that of B and D groups (P<0.05), and there was no statistical difference compared with group A (P>0.05); the agitation rate of group C at T2 time was lower than that of groups A and D (P<0.05), there was no statistical difference compared with group B (P>0.05); there was no statistical difference in the incidence of urinary catheter agitation among the four groups at T3 time (P>0.05). At the same time, with the extension of time, the restlessness rate of each group gradually decreased (P<0.05). The NRS score of group C at T1 time was lower than that of B and D groups (P<0.05), and there was no statistical difference compared with group A (P>0.05); the NRS score of group C at T2 time The score was lower than that of group A and D (P<0.05), and had no statistical difference compared with group B (P>0.05); the NRS score of group C at T3 time was lower than that of group A (P<0.05), and there was no statistical difference compared with group B and D (P>0.05); at the same time, with the prolongation of time, the NRS scores of groups B and C gradually decreased (P<0.05). Conclusion sThe combination of dyclonine hydrochloride mucilage with flurbiprofen axetil in men after general anesthesia endoscopic can significantly and consistently reduce the symptoms of bladder irritation caused by catheter and relieve pain, and the effect is better than that of single drug use, which is worthy of clinical promotion.

Key words: dyclonine hydrochloride mucilage, flurbiprofen axetil, catheter-related bladder discomfort

中图分类号:

R619.9

胡斌, 徐振海, 刘冰, 赵浩延, 陈学玲. 达克罗宁胶浆联合氟比洛芬酯预防男性全麻腔镜碎石术后导尿管所致膀胱刺激症状的效果[J]. 中华养生保健, 2022, 40(24): 45-48.

HU Bin, XU Zhen-hai, LIU Bing, ZHAO Hao-yan, CHEN Xue-ling. Effectiveness of Dyclonine Hydrochloride Mucilage Combined with Flurbiprofen Axetil for Prevention Catheter-Related Bladder Discomfort Caused by Urinary Tube Stimulation in Male Patients after General Anesthesia Endoscopic Lithotripsy[J]. ZHONGHUA YANGSHENG BAOJIAN, 2022, 40(24): 45-48.

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