血清TSH、TPO-Ab表达水平与老年甲状腺功能减退的相关性分析

摘要/Abstract

摘要： 目的探讨与分析血清促甲状腺激素（TSH）、甲状腺过氧化物酶抗体（TPO-Ab）表达水平与老年甲状腺功能减退的相关性。方法选取2018年1月~2021年12月在南京中医药大学附属南京市中西医结合医院诊治的老年甲状腺功能减退患者90例作为研究对象进行回顾性分析,其中原发性甲减40例为甲减组和亚临床甲减50例为亚甲减组,检测所有患者的血清TSH、TPO-Ab表达水平,同时检测患者的血脂与血红蛋白水平,分析血清TSH、TPO-Ab表达水平与老年甲状腺功能减退的相关性。结果甲减组与亚甲减组患者的血清TSH水平对比,差异无统计学意义（P>0.05）,甲减组患者的血清TPO-Ab含量明显高于亚甲减组,差异有统计学意义（P<0.05）。甲减组与亚甲减组患者的血红蛋白、血脂指标[甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）]对比差异无统计学意义（P>0.05）。甲减组患者的嗜睡、乏力等症状占比高于亚甲减组,差异有统计学意义（P<0.05）,甲减组与亚甲减组患者的怕冷、多汗、气短、心慌等症状占比差异无统计学意义（P>0.05）。在90例患者中,Pearson分析显示,血清TSH含量与亚临床甲减无相关性（P>0.05）,血清TPO-Ab与亚临床甲减存在显著相关性（P<0.05）。结论老年亚临床甲减为甲减的主要类型,血清TPO-Ab表达水平低于原发性甲减患者,血清TPO-Ab表达水平与老年亚临床甲减存在显著相关性,检测血清TSH、TPO-Ab表达水平有利于预测老年亚临床甲减的发生。

关键词: 老年人, 甲状腺功能减退, 甲状腺过氧化物酶抗体, 促甲状腺激素, 亚临床甲减, 相关性

Abstract: Objective To explore and analysis the correlation between the expression levels of serum Thyroid-stimulating hormone (TSH), Thyroid peroxidase antibody (TPO-Ab) and senile hypothyroidism. Methods A total of 90 elderly patients with hypothyroidism who were diagnosed and treated in Nanjing Hospital of Integrated Traditional Chinese and Western Medicine affiliated to Nanjing University of Traditional Chinese Medicine from January 2018 to December 2021 were retrospectively selected as the research subjects, and 40 cases of primary hypothyroidism and 50 cases of subclinical hypothyroidism were included. The serum TSH and TPO-Ab expression levels of the patients were detected. At the same time, the blood lipid and hemoglobin levels of the patients were detected, and the correlation between the expression levels of serum TSH and TPO-Ab and the elderly hypothyroidism was analyzed. Results There were no difference in serum TSH content compared between the two groups, and the difference was statistically significant (P<0.05). The serum TPO-Ab content in the hypothyroidism group were higher than that in the hypothyroidism group, and the difference was statistically significant (P<0.05). There were no difference in hemoglobin and blood lipid indexes [(triglycerides (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol(HDL-C)]compared between the two groups (P>0.05). The proportion of symptoms such as lethargy and fatigue in the hypothyroidism group were higher than that in the hypothyroidism group, the difference is statistically significant (P<0.05). In the 90 patients, Pearson analysis showed that serum TSH levels were not correlated with subclinical hypothyroidism (P>0.05), but serum TPO-Ab were correlated with subclinical hypothyroidism (P<0.05). Conclusion Subclinical hypothyroidism in the elderly is the main type of hypothyroidism. The expression level of serum TPO-Ab is lower than that in patients with primary hypothyroidism. There is correlation between the expression level of serum TPO-Ab and subclinical hypothyroidism in the elderly.Detection of serum TSH and TPO-Ab expression levels is helpful to predict the occurrence of subclinical hypothyroidism in the elderly.

Key words: elderly, hypothyroidism, thyroid peroxidase antibody, thyroid stimulating hormone, subclinical hypothyroidism, relevance

中图分类号:

R581.2

吴秉司. 血清TSH、TPO-Ab表达水平与老年甲状腺功能减退的相关性分析[J]. 中华养生保健, 2022, 40(24): 15-19.

WU Bing-si. Correlation Analysis of Serum TSH and TPO-Ab Expression Levels with Hypothyroidism in the Elderly[J]. ZHONGHUA YANGSHENG BAOJIAN, 2022, 40(24): 15-19.

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