非编码RNA调控口腔鳞癌增殖机制研究进展

中华养生保健 ›› 2022, Vol. 40 ›› Issue (20): 58-60.

非编码RNA调控口腔鳞癌增殖机制研究进展

江玉凤¹, 徐新立¹, 曹晓花^2,*

1.济宁市第一人民医院医学检验科,山东济宁,272100;
2.济宁市第一人民医院重症医学科,山东济宁,272100

出版日期:2022-10-16 发布日期:2022-10-14
通讯作者: ^*曹晓花,E-mail：zzyy8208@163.com。
作者简介:江玉凤（1988.8-）,女,汉族,籍贯：山东省济宁市,博士研究生,副主任技师,研究方向：临床检验诊断。
基金资助:
济宁市重点研发计划项目（2021YXNS004,2021YXNS119）; 国家重点研发计划（2019YFF0216502）; 济宁医学院实践教学教育科学研究项目（JYSJ2020B18）; 山东省医药卫生项目（202003100526）

Progress in Noncoding RNA Regulation Oral Squamous Cell Carcinoma Proliferation

JIANG Yu-feng¹, XU Xin-li¹, CAO Xiao-hua^2,*

1. Department of Medical Laboratory, Jining No. 1 People's Hospital, Jining Shandong, 272100, China;
2. Intensive Care Unit,Jining No. 1 People's Hospital, Jining Shandong, 272100, China

Online:2022-10-16 Published:2022-10-14

摘要/Abstract

摘要： 口腔鳞癌（oral squamous cell carcinoma,OSCC）是口腔颌面部最常见的恶性肿瘤,常向局部淋巴结转移,晚期可发生远处转移,严重影响患者的生存及生活质量。非编码RNA广泛存在于真核生物中,不能编码蛋白质的RNA包括miRNA、LncRNA、circRNA等。非编码RNA的异常调节在疾病发生发展中发挥着重要的调控作用,尤其在肿瘤发生发展过程中。非编码RNA调控OSCC增殖已成为研究热点,且已证明非编码RNA在OSCC发生发展中发挥着重要的调控作用。目前,有关非编码RNA在OSCC发生发展过程中的具体调控机制尚未完全明确,其已成为基础和临床亟需解决的科学问题。据此,本文对非编码RNA调控OSCC增殖机制研究进展进行综述与展望,以期为OSCC的发病机制及寻找新的治疗靶点提供借鉴与参考。

关键词: 非编码RNA, 口腔鳞癌, 增殖

Abstract: Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in oral and maxillofacial region. It often metastases to local lymph nodes, and distant metastasis may occur in late stage, which seriously affects the survival and quality of life of patients. Noncoding RNAs are widely found in eukaryotes, RNAs that cannot encode proteins, including miRNAs, LncRNAs, circRNAs, etc. The regulatory relationship between non-coding RNAs in the proliferation of OSCC has become a research hotspot, and it has been proved that non-coding RNAs play an important regulatory role in the occurrence and development of OSCC. At present, the specific regulatory mechanism of non-coding RNAs in the occurrence and development of OSCC has not been fully clarified, and it has become a scientific problem that needs to be solved urgently in basic and clinical practice. Therefore, we review the mechanisms of noncoding RNA regulation OSCC proliferation to provide theory foundation for OSCC diagnosis and treatment.

Key words: non-coding RNA, OSCC, proliferation

中图分类号:

R739.8

江玉凤, 徐新立, 曹晓花. 非编码RNA调控口腔鳞癌增殖机制研究进展[J]. 中华养生保健, 2022, 40(20): 58-60.

JIANG Yu-feng, XU Xin-li, CAO Xiao-hua. Progress in Noncoding RNA Regulation Oral Squamous Cell Carcinoma Proliferation[J]. ZHONGHUA YANGSHENG BAOJIAN, 2022, 40(20): 58-60.

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