三联局部外治法治疗斑秃的临床疗效

摘要/Abstract

摘要： 目的探讨三联局部外治法治疗斑秃的临床疗效。方法选择2021年12月~2022年3月贵阳市第一人民医院收治的100例斑秃患者为研究对象,按照随机数表法分为试验组和对照组,每组50例。试验组予以曲安奈德复合液皮损内注射+梅花针扣刺+域发头皮营养修复敷料外涂治疗,对照组仅予以曲安奈德复合液皮损内注射治疗。采用斑秃严重程度评分（SALT）和中文版皮肤病生活质量指数（DLQI）对两组患者进行评估,评价临床疗效。结果两组治疗前及治疗第1个月的SALT评分比较,差异无统计学意义（P>0.05）;治疗第2个月和第3个月试验组的SALT评分明显低于对照组,差异具有统计学意义（P<0.05）。试验组患者的有效率高于对照组,差异具有统计学意义（P<0.05）。两组治疗前DLQI评分比较,差异无统计学意义（P>0.05）;治疗后试验组DLQI评分低于对照组,差异具有统计学意义（P<0.05）。两组均无患者出现局部及全身不良反应。结论三联局部外治法治疗斑秃的疗效好,具有临床应用价值。

关键词: 斑秃, 三联局部外治法, 疗效

Abstract: Objective To explore the clinical efficacy of triple local external therapy in the treatment of alopecia areata. Methods Selected 100 patients with alopecia areata from December 2021 to March 2022 in Guiyang First People's Hospital, which were randomly divided into two groups, 50 patients in each group. The experimental group was treated with triamcinolone acetonide compound solution intralesional injection+plum blossom needle pricking+topical scalp nutrition repair dressing, while the control group was only treated with triamcinolone acetonide compound solution intralesional injection. Alopecia areata severity score (SALT) and Chinese version of dermatological quality of life index (DLQI) were used to evaluate the clinical efficacy and recurrence rate of the two groups. Results There was no significant difference in salt scores between the two groups before treatment and at the first month of treatment (P>0.05). The salt scores of the experimental group at the second and third months of treatment were significantly lower than those of the control group (P<0.05); The effective rate in the experimental group was higher than that in the control group (P<0.05); There was no significant difference in the DLQI score between the two groups before treatment (P>0.05), and the DLQI score of the experimental group was significantly lower than that of the control group after treatment (P<0.05); There were no local or systemic adverse reactions in both groups. Conclusion The triple local external therapy is effective in the treatment of alopecia areata.

Key words: alopecia areata, triple topical therapy, curative effect, recurrence rate

中图分类号:

R275

王妍清, 王海洪, 宋居艳, 杜雅婷. 三联局部外治法治疗斑秃的临床疗效[J]. 中华养生保健, 2022, 40(20): 16-18.

WANG Yan-qing, WANG Hai-hong, SONG Ju-yan, DU Ya-ting. Clinical Effect of Triple Local External Therapy on Alopecia Areata[J]. ZHONGHUA YANGSHENG BAOJIAN, 2022, 40(20): 16-18.

参考文献

[1] 中华医学会皮肤性病学分会毛发学组.中国斑秃诊疗指南(2019)[J].临床皮肤科杂志,2020,49(2):69-72.
[2] 孙春秋,毛雨,戴叶芹,等.中西医结合治疗多发性斑秃疗效及远期复发情况观察[J].中华中医药学刊,2017,35(4):1053-1056.
[3] 赵鹏,李鹏飞,秦俊霞,等.miR-6819-3p及其IL-17信号通路中靶基因在斑秃病变部位的表达[J].山西医科大学学报,2021,52(8):1053-1058.
[4] 章星琪. 国内外斑秃诊疗共识,指南的解读与启示[J].皮肤性病诊疗学杂志,2021,28(6):431-436.
[5] 王静文,武忠.斑秃的中医临床治疗研究概况[J].中国民族民间医药,2020,29(23):64-67.
[6] Olsen E A, Canfield D.SALT II: A new take on the Severity of Alopecia Tool (SALT) for determining percentage scalp hair loss[J]. Journal of the American Academy of Dermatology, 2016, 75(6):1268-1270.
[7] Weiss V C, West D P, Fu T S, et al.Alopecia areata treated with topical minoxidil[J]. Arch Dermatol, 1984, 120: 457-463.
[8] 王晓玲,赵天恩,张喜芹.简体中文版皮肤病生活质量指标信度和效度初探[J].中华流行病学杂志,2004,25(9):791-793.
[9] 侯占英,李华明.自拟补肾养血益精汤治疗斑秃的疗效及对血管内皮细胞生长因子和毛囊中相关分子表达的影响[J].中医药信息,2018,35(1):66-69.
[10] 荣蓉,拱远平,时文宁.FAS/FASLG基因多态性与鞍山地区汉族人群患斑秃的相关性研究[J].标记免疫分析与临床,2022,29(2):270-275.
[11] 李津津,张雪竹.滋水涵木通络法治疗肝肾不足型斑秃疗效及Th17/Treg相关机制研究[J].天津中医药,2019,36(6):568-571.
[12] 齐艳宁,魏波,吴琼,等.火针联合外用5%米诺地尔酊对肝肾不足型斑秃患者外周血Th17细胞,Treg细胞和心理状态的影响[J].现代生物医学进展,2022,22(8):1502-1505.
[13] 穆欣,张志灵,王瑞妮,等.复方倍他米松联合梅花针叩刺治疗斑秃临床疗效及其对P物质的影响[J].中国皮肤性病学杂志,2018, 32(3):362-365.
[14] 罗云玲,梅期钰.中西医结合治疗斑秃30例临床疗效观察[J].皮肤病与性病,2020,42(3):414-415.
[15] 刘媛媛,杨玉峰,张德华,等.天麻熄风汤联合米诺地尔酊治疗肝肾不足型斑秃疗效观察[J].广州中医药大学学报,2020,37(12):2337-2341.
[16] 范智琴,张艳,李封,等.脂脱搽剂配合梅花针及补肾养血胶囊治疗雄激素性脱发的临床观察[J].中医药导报,2019,25(7):87-90.
[17] 王美玲,刘娟,太景伟,等.梅花针的作用机理及临床应用进展[J].北京中医药大学学报(中医临床版),2019,26(5):61-65.
[18] 张雪松,周冬梅.祛湿健发汤联合梅花针扣刺治疗脾虚湿滞型脂溢性脱发的临床效果[J].中国医药导报,2019,16(25):126-129.
[19] 王瑶,孙晓岩.梅花针外治联合中药汤剂内服治疗对斑秃患者血液指标以及毛囊中相关分子表达的影响[J].临床和实验医学杂志,2015,14(12):996-999.
[20] 毛雨,戴叶芹,孙春秋,等.雄激素性脱发和斑秃患者生活质量及抑郁情况调查分析[J].中华皮肤科杂志,2017,50(5):360-363.