耳穴压豆联合柴胡疏肝散加减方治疗肺癌患者癌因性失眠的临床研究

摘要/Abstract

摘要： 目的探讨耳穴压豆联合柴胡疏肝散加减方治疗肺癌患者癌因性失眠的临床疗效。方法选取2021年1月~2022年1月在佛山市三水区人民医院就诊的80例肺癌癌因性失眠患者为研究对象,按照随机数表法分为观察组（耳穴压豆+柴胡疏肝散加减方）和对照组（艾司唑仑）,每组40例,对比两组临床疗效。结果观察组临床总有效率高于对照组,差异具有统计学意义（P<0.05）。治疗前和治疗3 d后,两组CD3⁺、CD4⁺、CD8⁺、CD4⁺/CD8⁺水平比较,差异无统计学意义（P>0.05）。治疗7 d后,观察组CD3⁺、CD4⁺、CD4⁺/CD8⁺水平均显著高于治疗前,差异具有统计学意义（P<0.05）;对照组CD4⁺水平高于治疗前,差异具有统计学意义（P<0.05）;治疗7 d后,观察组CD3⁺、CD4⁺、CD4⁺/CD8⁺水平均显著高于对照组,差异具有统计学意义（P<0.05）。两组天冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）、血尿素氮（BUN）和血肌酐（Cr）水平比较,差异无统计学意义（P>0.05）。治疗后,两组中医证候积分和SCL-90评分均低于治疗前,差异有统计学意义（P<0.05）;观察组中医证候积分和SCL-90评分均低于对照组,差异有统计学意义（P<0.05）。观察组不良反应发生率低于对照组,差异有统计学意义（P<0.05）。结论耳穴压豆联合柴胡疏肝散加减方治疗肺癌患者癌因性失眠的临床疗效显著,可有效改善免疫功能,安全性良好,值得临床应用。

关键词: 耳穴压豆, 柴胡疏肝散, 肺癌癌因性失眠¹

Abstract: Objective To explore the clinical effect of ear point pressing bean combined with Chaihu Shugan powder on cancer-related insomnia in patients with lung cancer. Methods A total of 80 patients with insomnia caused by lung cancer in Sanshui District People's Hospital from January 2021 to January 2022 were randomly divided into the observation group (pressing beans at ear points+Chaihu Shugan powder plus or minus formula) and the control group (estazolam). The clinical effects of the two groups were compared. Results The total effective rate of the observation group was significantly higher than that of the control group (P<0.05). There was no significant difference in the levels of CD3⁺, CD4⁺, CD8⁺, CD4⁺/CD8⁺ between the two groups before treatment and after 3 days of treatment (P>0.05). After 7 days of treatment, the levels of CD3⁺, CD4⁺, CD4⁺/CD8⁺ in the observation group were significantly higher than those before treatment (P<0.05); the levels of CD4⁺ in the control group were significantly higher than those before treatment (P<0.05). And the levels of CD3⁺, CD4⁺, CD4⁺/CD8⁺ in the observation group were significantly higher than those in the control group after 7 days (P<0.05). There was no significant difference in Aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN) and blood creatinine (Cr) levels between the two groups (P>0.05). After treatment, the TCM symptom score and SCL-90 score of the two groups were significantly lower than those before treatment (P<0.05), and the TCM symptom score and SCL-90 score of the observation group were significantly lower than those of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the observation group and the control group (P>0.05). Conclusion Auricular Point Pressing bean combined with Chaihu Shugan powder has a significant clinical effect in the treatment of cancer-related insomnia in patients with lung cancer. It can effectively improve immune function and has a good safety. It is worthy of clinical promotion.

Key words: auricular point pressing bean, Chaihu Shugan powder, insomnia caused by lung cancer

中图分类号:

R259

钟祖军. 耳穴压豆联合柴胡疏肝散加减方治疗肺癌患者癌因性失眠的临床研究[J]. 中华养生保健, 2022, 40(20): 12-15.

ZHONG Zu-jun. Clinical Study on Treatment of Cancer-related Insomnia in Patients with Lung Cancer by Pressing Beans at Ear Points Combined with Chaihu Shugan Powder[J]. ZHONGHUA YANGSHENG BAOJIAN, 2022, 40(20): 12-15.

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