不同丙泊酚剂量对无痛胃镜检查下老年患者疲劳综合征的影响

摘要/Abstract

摘要： 目的探讨不同丙泊酚剂量对无痛胃镜检查下老年患者术后疲劳综合征（Postoperative fatigue syndrome,POFS）的影响。方法选择2017年9月~2021年9月在江苏省南通市中医院进行无痛胃镜检查的70例老年患者作为研究对象,根据随机信封法把患者分为高剂量组与低剂量组,每组35例。所有患者均给予丙泊酚结合地佐辛静脉注射麻醉,高剂量组给予静脉注射丙泊酚2.0 mg/kg麻醉,低剂量组给予静脉注射丙泊酚1.0 mg/kg麻醉,记录术后疲劳综合征不良反应发生率、观察麻醉效果、血流动力学变化情况。结果低剂量组与高剂量组的意识消失时间对比,差异无统计学意义（P>0.05）,低剂量组的清醒时间、苏醒时间与高剂量组相比明显减少,差异有统计学意义（P<0.05）。低剂量组与高剂量组麻醉前与麻醉后10 min的血氧饱和度（pulse oxygen saturation,SpO₂）、心率（Heart rate,HR）、平均动脉压（Mean arterial pressure,MAP）在组内与组间对比,差异均无统计学意义（P>0.05）。低剂量组麻醉后24 h的呼吸抑制、呛咳、体动反应、恶心呕吐等不良反应发生率明显低于高剂量组,差异有统计学意义（P<0.05）。低剂量组的术后疲劳综合征发生率与持续时间均明显低于高剂量组,差异有统计学意义（P<0.05）。结论老年患者在进行无痛胃镜检查时,应用低剂量丙泊酚能有效缩短术后疲劳综合征发生时间,同时降低术后疲劳综合征发生率,不会影响患者的血流动力学状况,能促进患者康复,减少不良反应的发生。

关键词: 剂量, 丙泊酚, 无痛胃镜, 术后疲劳综合征, 清醒时间

Abstract: Objective To investigate the effect of different propofol dosages on postoperative fatigue syndrome (POFS) in elderly patients under painless gastroscopy. Methods From September 2017 to September 2021, 70 cases of elderly patients who underwent painless gastroscopy in Jiangsu Province Nantong City Hospital of Traditional Chinese Medicine were selected as the research objects. The patients were divided into high-dose group and low-dose group with 35 patients in each groups accorded to the principle of random envelope drawing. All patients were given intravenous anesthesia with propofol combined with dezocine, and the high-dose group was given intravenous propofol 2.0 mg/kg anesthesia, and low-dose group were given intravenous propofol 1.0mg/kg anesthesia. The postoperative fatigue syndrome and adverse reactions were recorded, and anesthesia effect and hemodynamic changes were observed. Results There were no significant difference in the time of disappearance of consciousness compared between the two groups (P>0.05). The low-dose group's awake time, wake-up time, and propofol dosage were less than the high-dose group ,and the difference was statistically significant(P<0.05). There were no significant difference in pulse oxygen saturation(SpO₂), Heart rate(HR) and Mean arterial pressure(MAP) compared between the two groups before and 10 min after anesthesia (P>0.05), and were all within the normal range. The incidence of adverse reactions such as respiratory depression, coughing, motor reactions, nausea and vomiting at 24 hours after anesthesia in the low-dose group were lower than high-dose group, and the difference was statistically significant(P<0.05). The incidence and duration of postoperative fatigue syndrome in the low-dose group were less than those in the high-dose group, and the difference was statistically significant(P<0.05). Conclusion In elderly patients undergoing painless gastroscopy, the application of low-dose propofol can effectively shorten the occurrence time of postoperative fatigue syndrome, and reduce the incidence of postoperative fatigue syndrome, without affecting the patient's hemodynamic status, and can promote patient recovery and reduce the occurrence of adverse reactions.

Key words: dose, propofol, painless gastroscopy, postoperative fatigue syndrome, wake time

中图分类号:

R614.2

王展. 不同丙泊酚剂量对无痛胃镜检查下老年患者疲劳综合征的影响[J]. 中华养生保健, 2022, 40(18): 22-25.

WANG Zhan. Effects of Different Doses of Propofol on Fatigue Syndrome in Elderly Patients Undergoing Painless Gastroscopy[J]. ZHONGHUA YANGSHENG BAOJIAN, 2022, 40(18): 22-25.

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