N-乙酰半胱氨酸联合HRZE方案治疗慢阻肺合并肺结核患者的疗效

摘要/Abstract

摘要： 目的探讨与分析N-乙酰半胱氨酸联合HRZE方案治疗慢阻肺合并肺结核的疗效。方法选择2018年9月~2022年1月在贵阳市公共卫生救治中心诊治的慢阻肺合并肺结核患者88例作为研究对象,根据随机数表法把患者分为N-乙酰半胱氨酸组与对照组,每组44例。对照组给予HRZE方案治疗,N-乙酰半胱氨酸组在对照组治疗基础上给予N-乙酰半胱氨酸治疗,两组均治疗观察3个月。比较两组患者治疗总有效率、肺功能指标[用力肺活量（FVC）、第1秒用力呼气容积（FEV₁）]、血清白细胞介素-6（IL-6）、不良反应发生率。结果 N-乙酰半胱氨酸组治疗后的总有效率略高于对照组,但差异无统计学意义（P>0.05）。治疗前,两组患者FVC、FEV₁经比较,差异无统计学意义（P>0.05）;治疗后,两组患者FVC占预计值百分比、FEV₁均高于治疗前,且N-乙酰半胱氨酸组高于对照组,差异有统计学意义（P<0.05）。治疗前,两组患者血清IL-6水平经比较,差异无统计学意义（P>0.05）;治疗后,两组患者血清IL-6水平均低于治疗前,且N-乙酰半胱氨酸组低于对照组,差异有统计学意义（P<0.05）。两组患者治疗期间不良反应发生率经比较,差异无统计学意义（P>0.05）。结论 N-乙酰半胱氨酸联合HRZE方案治疗慢阻肺合并肺结核能有效抑制血清炎症因子的表达,改善患者的肺功能,提高治疗效果,且不会增加不良反应。

关键词: N-乙酰半胱氨酸, HRZE方案, 慢性阻塞性肺疾病, 炎症因子, 肺功能, 不良反应

Abstract: Objective To investigate and analysis the efficacy of N-acetylcysteine combined with HRZE regimen in the treatment of patients with chronic obstructive pulmonary disease complicated with pulmonary tuberculosis. Methods Eighty-eight patients with chronic obstructive pulmonary disease and pulmonary tuberculosis who were diagnosed and treated in Guiyang Public Health Treatment Center from September 2018 to January 2022 were selected as the research subjects, and the patients were divided into N-acetylcysteine group and control group according to random number table. There were 44 cases in each group. The control group were treated with HRZE regimen, and the N-acetylcysteine group were treated with N-acetylcysteine based on the treatment of the control group. Both groups were treated for 3 months. The total effective rate, pulmonary function indicators [forced vital capacity (FVC), 1-second forced expiratory volume (FEV₁)], serum interleukin-6 (IL-6), and incidence of adverse reactions were compared between the two groups. Results The total effective rate in two groups during treatment was not significantly difference(P>0.05). There was no significant difference in FVC and FEV₁ between the two groups before treatment (P>0.05), were higher than those before treatment (P<0.05), and the N-acetylcysteine group was significantly higher than the control group (P<0.05). There was no significant difference in serum IL-6 content between the two groups before treatment (P>0.05). The serum IL-6 content in the two groups after treatment was significantly lower than before treatment (P<0.05). Acetylcysteine group was also significantly lower than the control group (P<0.05). The incidence of adverse reactions in two groups during treatment was not significantly difference(P>0.05). Conclusion N-acetylcysteine combined with HRZE regimen in the treatment of chronic obstructive pulmonary disease complicated with pulmonary tuberculosis can can effectively inhibit the expression of serum inflammatory factors, improve the patient's pulmonary function, and improve the therapeutic effect, increase the occurrence of adverse reactions.

Key words: N-acetylcysteine, HRZE regimen, chronic obstructive pulmonary disease, inflammatory factors, pulmonary function, adverse reactions

中图分类号:

R563.9

李晓英, 陈璇. N-乙酰半胱氨酸联合HRZE方案治疗慢阻肺合并肺结核患者的疗效[J]. 中华养生保健, 2022, 40(18): 15-18.

LI Xiao-ying, CHEN Xuan. Efficacy of N-acetylcysteine Combined with HRZE Regimen in the Treatment of Patients with Chronic Obstructive Pulmonary Disease Complicated with Pulmonary Tuberculosis[J]. ZHONGHUA YANGSHENG BAOJIAN, 2022, 40(18): 15-18.

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