血清生长抑素和降钙素基因相关肽表达水平的联合检测对腹腔镜下胆囊切除术后患者胃肠功能恢复的预测价值分析

摘要/Abstract

摘要： 目的探究血清生长抑素（SS）和降钙素基因相关肽（CGRP）的表达水平对腹腔镜下胆囊切除术后患者胃肠功能恢复的预测价值。方法回顾性选择2017年1月~2020年12月喀什地区第二人民医院收治的200例行腹腔镜下胆囊切除术的患者作为研究对象,依据术后胃肠功能恢复情况将所有患者分为恢复良好组和较差组。收集所有患者的临床资料,采用酶联免疫吸附法检测血清SS和CGRP的表达水平,应用受试者工作特征曲线（ROC）判定各指标单项检测和联合检测对胃肠道功能恢复的预测价值。结果恢复良好组和较差组患者的性别、年龄、BMI、ASA分级、手术时间、PACU停留时间、总入液量和出血量等方面相比,差异无统计学意义（P>0.05）,而在术后首次排气时间、术后首次排便时间和肠鸣音恢复时间上,恢复良好组短于较差组,差异有统计学意义（P<0.05）。术后胃肠功能恢复期,较差组患者血清SS和CGRP的表达水平显著高于恢复良好组,差异有统计学意义（P<0.05）。SS+CGRP联合检测对术后胃肠功能恢复情况的预测价值高于SS或CGRP单项检测的预测价值。结论血清SS和CGRP的表达水平可作为预测腹腔镜下胆囊切除术后胃肠功能恢复情况的重要生物学指标,且联合检测具有更高的预测价值,可为临床及早干预、改善患者预后提供重要的参考。

Abstract: Objective To investigate the predictive value of detection of serum somatostatin(SS) and calcitonin gene-related peptide(CGRP) in predicting gastrointestinal function recovery of patients after laparoscopic cholecystectomy. Methods A total of 200 patients undergoing laparoscopic cholecystectomy who were admitted to the Second People’s Hospital of Kashgar from January 2017 to December 2020 were included as research subjects, all patients were divided into well recovered group and poor recovered group according to recovery condition of gastrointestinal function. All clinical data were collected, the expression levels of serum SS and CGRP of all patients were detected by ELISA, the predictive value each index was evaluated by receiver operating characteristic curve(ROC). Results The sexuality, age, BMI, ASA grading, operation time, PACU residence time, total liquid intake and blood loss of two groups had no statistically significant difference(P>0.05), the good group was shorter than the poor group in terms of the time to first exhaust after operation, the time to first defecation after operation and the recovery time of bowel sounds,the difference was statistically significant(P<0.05). The expression levels serum SS and CGRP of poor recovered group were higher than well recovered group, the difference was statistically dignificant (P<0.05). ROC analysis showed that the AUC, sensitivity and specificity of SS+CGRP were higher than separate detection of two indexes. Conclusion The expression levels of serum SS and CGRP could be important factors in predicting recovery condition of gastrointestinal function after laparoscopic cholecystectomy, and combined detection of two indexes had higher predictive value, while could provide reference for early intervention and improvement of postoperative recovery.

Key words: somatostatin, calcitonin gene-related peptide, laparoscopic cholecystectomy, gastrointestinal function, predictive value

中图分类号:

R604

童万勇, 唐水斌. 血清生长抑素和降钙素基因相关肽表达水平的联合检测对腹腔镜下胆囊切除术后患者胃肠功能恢复的预测价值分析[J]. 中华养生保健, 2022, 40(16): 15-18.

TONG Wan-yong, TANG Shui-bin. Predictive Value Analysis of the Combined Detection of Serum Somatostatin and Calcitonin Gene-Related Peptide Expression Levels in Patients with Gastrointestinal Recovery after Laparoscopic Cholecystectomy[J]. ZHONGHUA YANGSHENG BAOJIAN, 2022, 40(16): 15-18.

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