稳定性冠心病血清炎性指标、血脂血糖与预后的关系

摘要/Abstract

摘要： 目的探讨稳定性冠心病血清炎性指标、血脂血糖与预后的关系。方法选取2019年2月~2022年2月江苏省中医院收治的120例稳定性冠心病患者作为研究对象,依照所有患者白细胞介素-6（IL-6）、高敏C反应蛋白（hs-CRP）、甘油三酯（TG）、空腹血糖（FPG）水平进行分组。所有患者以IL-6中位水平为2.1 ng/L分组,分为<2.1 ng/L组（n=54）和≥2.1 ng/L（n=66）组;以hs-CRP中位水平为1.3 mg/L分组,分为<1.3 mg/L组（n=58）和≥1.3 mg/L（n=62）组;并依照TG中位水平分为1.7 mmol/L分组,分为<1.7 mmol/L组（n=45）和≥1.7 mmol/L组（n=75）;并依照FPG中位水平为7.0 mmol/L分组,分为<7.0 mmol/L组（n=52）和≥7.0 mmol/L组（n=68）;对比IL-6、hs-CRP、TG、FPG不同水平患者的临床特征与预后情况,并应用Cox回归分析,分析IL-6、hs-CRP、TG、FPG与稳定性冠心病患者预后的相关性。结果不同IL-6水平患者心血管疾病死亡、肾功能不全、心肌梗死、心力衰竭、心衰再入院对比,差异有统计学意义（P<0.05）;不同的hs-CRP水平患者高血压、心血管疾病死亡、肾功能不全、心肌梗死、心力衰竭、心衰再入院对比,差异有统计学意义（P<0.05）;不同TG水平患者肾功能不全、心衰再入院对比,差异有统计学意义（P<0.05）;不同FPG水平患者糖尿病、肾功能不全、心衰再入院对比,差异有统计学意义（P<0.05）;回归分析结果表明,高IL-6、hs-CRP、TG、FPG水平均为稳定性冠心病不良预后的独立影响因素（P<0.05）。结论 IL-6与hs-CRP是稳定性冠心病患者心血管疾病死亡、心肌梗死、心力衰竭以及心衰再入院的独立危险因素,IL-6与hs-CRP可能参与了这些事件发生的病理生理过程,而TG、FPG水平多为肾功能不全、心衰再入院的独立危险因素。

关键词: 稳定性冠心病, 炎性指标, 血糖, 血脂, 心力衰竭

Abstract: Objective To investigate the relationship between serum inflammatory indexes, blood lipid and blood glucose and prognosis of stable coronary heart disease. Methods One hundred and twenty patients with stable coronary heart disease treated in our hospital from February 2019 to February 2022 were selected as the research object. All patients were divided into groups according to the levels of interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), triglyceride (TG) and fasting blood glucose (FPG).The median level of IL-6 in all patients was 2.1 ng/L, which were divided into <2.1 ng/L group (n= 54) and ≥2.1 ng/L group (n=66). The median level of hs-CRP was 1.3 mg/L, which was divided into <1.3 mg/L group (n=58) and ≥1.3 mg/L group (n=62). According to the level of TG, it was divided into <1.7 mmol/L group (n=45) and >1.7 mmol/L group (n=75), and according to the level of FPG, it was divided into <7.0 mmol/L group (n=52) and >7.0 mmol/L group (n=68). The clinical characteristics and prognosis of patients with different levels of IL-6, hs-CRP, TG and FPG were compared. Cox regression analysis was used to analyze the clinical characteristics and prognosis of IL-6, hs-CRP, TG Correlation between FPG and prognosis of patients with stable coronary heart disease. Results There were statisticalsignificant differences in cardiovascular death, renal insufficiency, myocardial infarction, heart failure, and heart failure readmission in patients with different IL-6 levels (P<0.05). There were statisticalsignificant differences in hypertension, cardiovascular death, renal insufficiency, myocardial infarction, heart failure, and heart failure readmission in patients with different hs-CRP levels (P<0.05). There were statisticalsignificant differences in renal insufficiency and heart failure readmission in patients with different TG levels (P<0.05). There were statisticalsignificant differences among patients with diabetes mellitus, renal insufficiency, and heart failure readmissions among patients with different FPG levels (P<0.05). The results of regression analysis showed that high levels of IL-6, hs-CRP, TG and FPG were independent factors affecting the poor prognosis of stable coronary heart disease (P<0.05).Conclusion IL-6 and hs-CRP are independent risk factors for cardiovascular death, myocardial infarction, heart failure and readmission of heart failure in patients with stable coronary heart disease. IL-6 and hs-CRP may be involved in the pathophysiological process of these events, while TG and FPG levels are mostly independent risk factors for readmission of renal insufficiency and heart failure.

Key words: stable coronary heart disease, inflammatory index, blood glucose, blood lipids, heart failure

中图分类号:

杨琳, 梁鑫, 李全. 稳定性冠心病血清炎性指标、血脂血糖与预后的关系[J]. 中华养生保健, 2022, 40(14): 8-11.

YANG Lin, LIANG Xin, LI Quan. Relationship Between Serum Inflammatory Index, Blood Lipid and Blood Glucose and Prognosis of Stable Coronary Heart Disease[J]. ZHONGHUA YANGSHENG BAOJIAN, 2022, 40(14): 8-11.

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