复方苦参注射液与化疗联合应用于结直肠癌患者中的效果研究

摘要/Abstract

摘要： 目的探讨复方苦参注射液与化疗联合应用于结直肠癌患者中的效果。方法选取2019年8月~2021年7月滨州市中心医院收治的64例结直肠癌患者为研究对象,以随机数表法分为两组,每组32例。对照组患者接受常规化疗治疗,研究组在基础上联合使用复方苦参注射液。对比两组患者临床疗效、治疗前后的免疫细胞[T淋巴细胞分化簇4⁺（CD4⁺）、分化簇8⁺（CD8⁺）、CD4⁺/CD8⁺与自然杀伤细胞（NK）]、生活质量测定量表（QLQ-C30）评分、骨髓抑制、胃肠道反应以及肝功能异常率。结果在总有效率结果对比中,研究组高于对照组,差异有统计学意义（P<0.05）。治疗前,在免疫细胞CD4⁺、CD8⁺、CD4⁺/CD8⁺及NK水平对比中,两组结果差异无统计学意义（P>0.05）;治疗后,研究组CD4⁺、CD4⁺/CD8⁺、NK细胞指标高于对照组,CD8⁺水平低于对照组,差异有统计学意义（P<0.05）。治疗前,在QLQ-C30量表中各项分值对比中,两组结果差异无统计学意义（P>0.05）;治疗后,研究组QLQ-C30量表中躯体、社会功能、情绪、认知、角色分值高于对照组,差异有统计学意义（P<0.05）。在胃肠道反应及骨髓抑制比较中,研究组发生率低于对照组,差异有统计学意义（P<0.05）;肝功能异常发生率对比中,两组结果差异无统计学意义（P>0.05）。结论结直肠癌患者应用复方苦参注射液联合化疗进行治疗,效果显著,进一步改善了免疫功能,缓解化疗不良反应,保障生活质量,具有临床应用价值。

关键词: 复方苦参注射液, 化疗, 结直肠癌, 免疫功能, 生活质量

Abstract: Objective To analysis of compound Sophora flavescens injection combined with chemotherapy in research object with colorectal cancer. Methods Sixty-four patients with colorectal cancer treated in Binzhou Central Hospital from August 2019 to July 2021 were random grouping ,there was two groups with 32 cases in each group. The research object in the control group were treated with routine chemotherapy, and the patients in the study group were treated with compound Sophora flavescens injection on the basis of routine chemotherapy. Before and after treatment,the clinical efficacy, immune cells [T lymphocyte differentiation Cluster 4⁺ (CD4⁺), differentiation cluster 8⁺ (CD8⁺), CD4⁺ / CD8⁺ and natural killer cells (NK)] and quality of lifequestionnaire (QLQ-C30) scores ,and the rates of bone marrow suppression, gastrointestinal reaction and abnormal liver function were compared. Results The total effective rate of the study group was higher than that of the control group (P<0.05). In the comparison of CD4⁺, CD8⁺, CD4⁺ / CD8⁺ and NK levels before treatment, there was no difference between the two groups (P>0.05); The level of CD4⁺and CD4⁺ / CD8⁺ and NK cells in the study group after treatment, was higher than the control group (P<0.05), and the level of CD8⁺ was lower than that in the control group (P<0.05). There was no difference in QLQ-C30 score between the two groups before treatment (P>0.05); After treatment, the scores of body, social function, emotion, cognition and role of QLQ-C30 were higher than the control group (P<0.05). The incidence of gastrointestinal reaction and bone marrow suppression in the study group was lower than that in the control group (P<0.05); There was no difference in the rate of abnormal liver function between the two groups (P>0.05). Conclusion The application of compound Sophora flavescens injection in patients with colorectal cancer on the basis of routine chemotherapy has significant effect, further improves immune function, alleviates adverse reactions of chemotherapy, and ensures the quality of life. It has clinical application value.

Key words: compound Sophora flavescens injection, chemotherapy, colorectal cancer, immunity, quality of life

中图分类号:

R735.3

赵华, 赵胃胃, 马书美. 复方苦参注射液与化疗联合应用于结直肠癌患者中的效果研究[J]. 中华养生保健, 2022, 40(14): 12-15.

ZHAO Hua, ZHAO Wei-wei, MA Shu-mei. Effect of Compound Sophora Flavescens Injection Combined with Chemotherapy in Patients with Colorectal Cancer[J]. ZHONGHUA YANGSHENG BAOJIAN, 2022, 40(14): 12-15.

参考文献

[1] 马守东,房丽,李海丽,等.卡培他滨节拍化疗联合复方苦参注射液治疗晚期结直肠癌的临床疗效观察[J].中国煤炭工业医学杂志,2019,22(4):351-355.
[2] 张彬,莫伟明,阮勇.复方苦参注射液结合FOLFOX4方案治疗结直肠癌的相关指标变化分析[J].世界中医药,2019,14(6):1485-1489.
[3] 陈宏宏,苏颜平.艾迪注射液联合XELOX化疗对晚期结直肠癌的临床疗效及安全性观察[J].贵州医药,2022,46(1):54-55.
[4] 伊凡,王子怡,刘少康,等.中医药联合化疗在结直肠癌临床治疗作用中的系统评价[J].世界科学技术-中医药现代化,2019,21(2):148-154.
[5] 孔明,杨亚娟.补气益肾方联合化疗对老年结直肠癌患者血清肿瘤标志物及免疫功能的影响[J].河南医学研究,2021,30(35):6654-6657.
[6] 中华人民共和国卫生和计划生育委员会医政医管局,中华医学会肿瘤学分会.中国结直肠癌诊疗规范(2017年版)[J].中华外科杂志,2018,56(4):241-258.
[7] 孙燕,石远凯.临床肿瘤内科手册(第5版)[M].北京:人民卫生出版社,2007:152-153.
[8] 王剑新,曹亮,韩娟,等.健脾解毒方加减联合FOLFOX4方案对结直肠癌化疗患者的临床疗效[J].中成药,2021,43(11):3258-3261.
[9] 贾雪丽,杨彦,孙予祥.中药复方肠复康抗结直肠癌血管生成作用靶基因网络药理学研究[J].中华中医药学刊,2020,38(3):246-251,后插21.
[10] 孟丹,江联萍,朱莹杰.以健脾为主的中药治疗对青年晚期结直肠癌腹膜转移预后的影响[J].中华中医药杂志,2019,34(12):5885-5888.
[11] 李妍琦. 复方苦参注射液对晚期结直肠癌化疗者营养状况及免疫功能的影响[J].中国肛肠病杂志,2021,41(11):14-15.
[12] 王振滔. 复方苦参注射液联合FOLFOX4方案化疗在晚期结直肠癌患者术后治疗中的应用[J].中国肛肠病杂志,2021,41(2):9-11.
[13] 宋文杰. 复方苦参注射液联合化疗治疗晚期结肠癌临床研究[J].辽宁中医杂志,2021,48(8):159-160.
[14] 尹宏,赖思帧,张春泽,等.复方苦参注射液联合化疗对结直肠癌患者术后营养状况、免疫功能、炎性因子水平及生活质量的影响[J].中国中西医结合外科杂志,2020,26(3):457-464.
[15] 张小燕,侯晓春.参芪扶正注射液联合XELOX化疗对老年结直肠癌患者T淋巴细胞亚群、CEA、CA125和CA724及生存质量的影响[J].中国老年学杂志,2021,41(23):5201-5203.
[16] 张静,张帆,韩克松,等.免疫功能水平与腹腔镜结直肠癌根治术后复发的相关性研究[J].中国中西医结合外科杂志,2022,28(1):42-46.
[17] 李程,应伟.复方苦参注射液联合XELOX方案对晚期结肠癌患者疗效及免疫功能的影响[J].标记免疫分析与临床,2019,26(2):318-321.