视网膜厚度联合视网膜中央血管血流速度对非增殖期2型糖尿病视网膜病变患者的诊断价值分析

摘要/Abstract

摘要： 目的探讨与分析视网膜厚度联合视网膜中央血管血流速度对非增殖期2型糖尿病视网膜病变患者的诊断价值。方法使用简单随机抽样法,选择2019年2月~2021年6月在佛山市中医院三水医院治疗的非增殖期2型糖尿病视网膜病变患者122例作为非增殖期组,选择同期在佛山市中医院三水医院进行诊治的增殖期2型糖尿病视网膜病变患者122例作为增殖期组。采用光学相干断层成像（optical coherence tomography,OCT）检测视网膜厚度,同时用彩色超声多普勒诊断仪检测患者视网膜中央血管血流速度并进行相关性、影响因素、诊断价值分析。结果非增殖期组的视网膜MRT与CMT都明显低于增殖期组,对比差异有统计学意义（P<0.05）。非增殖期组的视网膜中央动脉最大血流速度（PSV）和视网膜中央静脉最大血流速度（Vmax）都明显高于增殖期组,对比差异有统计学意义（P<0.05）。在两组244例患者中,Pearson相关分析显示非增殖期2型糖尿病视网膜病变与视网膜MRT、CMT厚度和视网膜中央血管流速PSV、Vmax都存在显著相关性（P<0.05）。多元线性逐步回归分析显示视网膜MRT、CMT厚度和视网膜中央动脉最大血流速度（PSV）和视网膜中央静脉最大血流速度（Vmax）都为导致非增殖期2型糖尿病视网膜病变发生的重要因素（P<0.05）。受试者工作特征（receiver operating characteristic curve,ROC）曲线分析显示视网膜厚度联合视网膜中央血管血流速度对非增殖期2型糖尿病视网膜病变患者的曲线下面积为0.820。结论非增殖期2型糖尿病视网膜病变患者可能伴随视网膜厚度降低与视网膜中央血管血流速度上升,视网膜厚度、视网膜中央血管血流速度与非增殖期2型糖尿病视网膜病变存在相关性,两者联合诊断非增殖期2型糖尿病视网膜病变具有很高的价值。

关键词: 非增殖期2型糖尿病视网膜病变, 视网膜厚度, 视网膜中央血管血流速度, 相关性, 诊断价值

Abstract: Objective To explore and analyze the diagnostic value of retinal thickness combined with central retinal blood flow velocity in patients with non-proliferative type 2 diabetic retinopathy. Methods From February 2019 to June 2021, used the simple random sampling method, 122 cases of patients with non-proliferative type 2 diabetic retinopathy who were diagnosed and treated in Foshan Hospital of Traditional Chinese Medicine Sanshui Hospital, were selected as then on-proliferative group. And the other 122 cases with proliferative type 2 diabetic retinopathy in Department of Ophthalmology, Foshan Hospital of Traditional Chinese Medicine Sanshui Hospital, during the same period were selectedas the proliferative group. The retinal thickness was detected by optical coherence tomography (OCT), and the blood flow velocity of the central retinal blood vessels was detected by color Doppler diagnostic instrument,the correlation, influencing factors and diagnostic value was analyzed. Results The retinal MRT and CMT in the non-proliferative group were significantly lower than those in the proliferative group, the difference is statistically significant (P<0.05). The maximum blood flow velocity of central retinal artery (PSV) and the maximum blood flow velocity of central retinal vein (Vmax) in the non-proliferative group were significantly higher than those in the proliferative group, the difference is statistically significant (P<0.05). In two groups of 244 patients, pearson correlation analysis showed that non-proliferative type 2 diabetic retinopathy was significantly correlated with retinal MRT, CMT thickness, central retinal vascular velocity PSV, Vmax (P<0.05). Multiple linear stepwise regression analysis showed that retinal MRT, CMT thickness, maximum central retinal artery blood flow velocity (PSV) and central retinal vein maximum blood flow velocity (Vmax) were all important factors leading to non-proliferative type 2 diabetic retinopathy (P<0.05). Receiver operating characteristic curve (ROC) curve analysis showed that the area under the curve of retinal thickness combined with central retinal blood flow velocity for non-proliferative type 2 diabetic retinopathy patients was 0.820. Conclusion Patients with non-proliferative type 2 diabetic retinopathy may be accompanied by decreased retinal thickness and increased central retinal blood flow velocity. There is a correlation between retinal thickness and central retinal blood flow velocity and non-proliferative type 2 diabetic retinopathy. The combined diagnosis of non-proliferative type 2 diabetic retinopathy has high value.

Key words: nonproliferative type 2 diabetic retinopathy, retinal thickness, central retinal blood flow velocity, correlation, diagnostic value

中图分类号:

R774.1

李小艳. 视网膜厚度联合视网膜中央血管血流速度对非增殖期2型糖尿病视网膜病变患者的诊断价值分析[J]. 中华养生保健, 2022, 40(12): 8-12.

LI Xiao-yan. the Diagnostic Value of Retinal Thickness Combined with Central Retinal Blood Flow Velocity in Patients with Non-Proliferative Type 2 Diabetic Retinopathy[J]. ZHONGHUA YANGSHENG BAOJIAN, 2022, 40(12): 8-12.

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