基于Neo4j知识图谱探讨“对药”理论下中医治疗溃疡性结肠炎临床用药规律

摘要/Abstract

摘要： 目的通过Neo4j知识图谱,探寻中医药治疗溃疡性结肠炎“对药”规律。方法检索2020年1月1日—2024年12月1日中国知网数据库内有关中医药治疗溃疡性结肠炎的临床研究类文献,收集其中包含的中医处方、证型、搭配的中医操作、搭配的西药等数据,对处方数据中的中药进行性味归经、拆分功效数据统计,将所有数据进行频率、频次、加权频次统计,并对中药口服方与中药灌肠方、中药处方与其自身之间的关系进行权值、置信度、提升度的计算,后将数据导入至Neo4j图数据库。结果共统计有效数据242条,频率≥50%的口服中药有白术、黄连、白芍;频率≥50%的灌肠中药有白及、黄柏;频率≥10%的证型仅有大肠湿热;频率≥10%的搭配的其他操作有艾灸、针刺、耳穴压豆、穴位埋线;频率≥10%的搭配的西药仅有美沙拉嗪。导入知识图谱后,满足频率≥10%、置信度≥65%、提升度≥1、以前置词频率降序排列第一位的中药口服方与中药口服方关系是白芍→白术;中药灌肠方与中药灌肠方关系是白及→黄柏;归经频率排序前5为脾、肝、胃、肺、大肠;药性频率排序前5为寒、温、平、凉、热;药味频率前5为苦、甘、辛、涩、酸;拆分功效频率前5为解毒、清热、止痛、燥湿、止血。结论通过Neo4j知识图谱分析,揭示了中医治疗溃疡性结肠炎“对药”规律,白术、白芍、黄连等中药的口服方和白及、黄柏等灌肠方具有较高的应用频率,并且在治疗过程中,脾、肝、胃、大肠的经络涉及较多。该研究为中医药治疗溃疡性结肠炎提供了理论依据,且为临床用药决策提供了参考。

关键词: Neo4j, 溃疡性结肠炎, 知识图谱, 中医, 对药

Abstract: Objective Through the Neo4j knowledge graph, explore the "medication" pattern of traditional Chinese medicine in treating ulcerative colitis. Method Retrieve clinical research literature on the treatment of ulcerative colitis with traditional Chinese medicine from the China National Knowledge Infrastructure (CNKI) database from January 1, 2020 to December 1, 2024. Collect data on traditional Chinese medicine prescriptions, syndrome types, combined traditional Chinese medicine operations, and combined Western medicine. Perform statistical analysis on the properties, flavors, meridians, and efficacy of traditional Chinese medicine in the prescription data. Perform frequency, frequency, and weighted frequency statistics on all data. Calculate the weight, confidence, and enhancement of the relationship between traditional Chinese medicine oral formulas, traditional Chinese medicine enema formulas, and traditional Chinese medicine prescriptions themselves. Then import the data into the Neo4j graph database. Result A total of 242 valid data were collected, and the oral Chinese medicines with a frequency of≥50% included Atractylodes macrocephala, Coptis chinensis, and Paeonia lactiflora; The enema herbs with a frequency of ≥50% include Bai Ji and Huang Bai; The only type of syndrome with a frequency of ≥10% is damp heat in the large intestine; Other operations with a frequency of ≥10% include moxibustion, acupuncture, ear acupressure, and acupoint embedding; The only Western medicine with a frequency of ≥10% is mesalazine. After importing the knowledge graph, the relationship between traditional Chinese medicine oral formulas that meet the criteria of frequency ≥10%, confidence ≥65%, improvement≥1, and ranked first in descending order of previously placed word frequency is from Paeonia lactiflora to Atractylodes macrocephala; The relationship between traditional Chinese medicine enema formula and traditional Chinese medicine enema formula is Bai Ji → Huang Bai; The top 5 in terms of meridian frequency are spleen, liver, stomach, lungs, and large intestine; The top 5 in terms of frequency of medicinal properties are cold, warm, flat, cool, and hot; The top 5 medicinal flavors are bitter, sweet, spicy, astringent, and sour; The top 5 efficacy frequencies for splitting are detoxification, clearing heat, relieving pain, drying dampness, and stopping bleeding. Conclusion The analysis using the Neo4j knowledge graph reveals the "pairing drug" patterns in TCM for treating UC. The oral herbs Atractylodes, Peony, and Coptis, along with the enema herbs Bletilla and Phellodendron, were frequently used. The Spleen, Liver, Stomach, and Large Intestine meridians were commonly involved in the treatment process. This study provides a theoretical basis for TCM in the treatment of UC and offers clinical reference for drug selection.

Key words: Neo4j, ulcerative colitis, knowledge graph, Chinese medicine, regarding medication

中图分类号:

R259

许涛, 张薇. 基于Neo4j知识图谱探讨“对药”理论下中医治疗溃疡性结肠炎临床用药规律[J]. 中华养生保健, 2025, 43(9): 1-6.

XU Tao, ZHANG Wei. Exploring the Clinical Medication Patterns of Traditional Chinese Medicine in the Treatment of Ulcerative Colitis with the “Duiyao” Theory based on the Neo4j Knowledge Graph Theory[J]. ZHONGHUA YANGSHENG BAOJIAN, 2025, 43(9): 1-6.

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