虫类药在类风湿关节炎中的应用规律分析

摘要/Abstract

摘要： 目的探讨名老中医运用虫类药治疗类风湿关节炎（RA）的应用规律,为虫类药的临床应用提供一定参考。方法本研究收集名老中医运用虫类药治疗RA的现代医案,构建结构化医案数据库,利用古今医案云平台对处方进行频数统计、关联分析及聚类分析,以数据形式呈现虫类药在RA中的应用规律。结果经统计症状数据115条,证型32种,其中频次较高的为瘀血阻络证、湿热痹阻证。含虫类药处方188首,涉及213味中药,其中虫类药28种,高频虫类药包括穿山甲、全蝎、乌梢蛇等。从处方组成来看,虫类药在处方中所占比例不高。从用量来看,虫类药在处方中用量偏小。从中药性味归经来看,四气中温性药、平性药使用频次最多,五味中甘、辛、苦使用频次最多,主要归肝、脾经。关联规则共得出含虫类药药对21对,其中频次≥30次的6对,聚类分析共得到1组多味药组合和3组药对。结论名老中医治疗RA处方中常用穿山甲、全蝎、乌梢蛇、地龙、蜈蚣等虫类药,多与补虚药、祛风除湿药、活血化瘀药等配伍使用,其中全蝎-黄芪药对使用频次最高。

关键词: 虫类药, 类风湿关节炎, 医案, 数据挖掘, 古今医案云平台

Abstract: Objective To investigate the application of insect drugs in the treatment of rheumatoid arthritis (RA) by famous old Chinese medicine, and to provide some reference for the clinical application of insect drugs. Methods In this study, the modern medical records of traditional Chinese medicine practitioners using insect drugs to treat RA were collected, a structured medical records database was built, and the frequency statistics, association analysis and cluster analysis of prescriptions were carried out using the cloud platform of ancient and modern medical records to present the application rules of insect drugs in RA in the form of data. Results There were 115 statistical data of symptoms and 32 types of symptoms, among which the most frequent were the syndrome of blood stasis blocking collaterals and the syndrome of damp-heat blocking. There were 188 prescriptions of insect-containing drugs, involving 213 kinds of traditional Chinese medicine, of which 28 kinds were insect-containing drugs, and high-frequency insect-containing drugs included pangolin, scorpion, and Wuzao snake. From the perspective of prescription composition, the proportion of insect drugs in prescriptions is not high. From the point of view of dosage, the dosage of insect drugs in the prescription is small. From the point of view of TCM flavor, the use of the four qi middle-temperature drugs and flat drugs is the most frequent, and the use of the five tastes of Gan, Xin and bitter is the most frequent, mainly under the liver and spleen channels. A total of 21 insect-containing drug pairs were obtained by association rules, including 6 pairs with frequency ≥30 times, and 1 group of multi-flavor drug combinations and 3 groups of drug pairs were obtained by cluster analysis. Conclusion Pangolin, scorpion, Wuzao snake, Earthdragon, centipede and other insect drugs are commonly used in the prescription of traditional Chinese medicine in the treatment of RA, and most of them are used in combination with the drugs for toning deficiency, dispelling wind and removing dampness, promoting blood circulation and removing blood stasis, among which the scorpion and Astragalus pair are used most frequently.

Key words: insecticides, rheumatoid arthritis, medical records, data mining, ancient and modern medical records cloud platform

中图分类号:

R255.6

孟宇航, 梁佳, 杨卫彬. 虫类药在类风湿关节炎中的应用规律分析[J]. 中华养生保健, 2025, 43(8): 1-6.

MENG Yuan-hang, LIANG Jia, YANG Wei-bin. Analysis of the Application of Insect Drugs in Rheumatoid Arthritis[J]. ZHONGHUA YANGSHENG BAOJIAN, 2025, 43(8): 1-6.

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