经颅多普勒发泡试验阳性与脑梗死病理特征的相关性分析

摘要/Abstract

摘要： 目的探讨与分析经颅多普勒发泡试验（control-enhanced transcranial doppler,c-TCD）阳性与脑梗死病理特征的相关性。方法选择2020年1月~2022年4月在苏州大学附属第三医院诊治的脑梗死患者137例,给予所有患者经颅多普勒发泡试验检查,根据微气泡信号判定状况进行分组,发泡阳性组73例,发泡阴性组64例。调查两组患者的一般资料、血常规资料、病理特征并进行相关性分析。结果发泡阳性组占53.3%,其中Ⅰ级40例,Ⅱ级20例,Ⅲ级13例。发泡阳性组的受教育年限、体质量指数、年龄、血压与发泡阴性组对比,差异无统计学意义（P>0.05）。两组的血糖、血小板计数、纤维蛋白原、D-二聚体、血红蛋白等对比,差异无统计学意义（P>0.05）。发泡阳性组的反常性栓塞量表（RoPE）评分明显低于发泡阴性组,病程、家族史发生率明显高于发泡阴性组,差异有统计学意义（P<0.05）,两组病程、梗死类型、梗死部位等对比,差异有统计学意义（P>0.05）。在73例患者中,Spearman相关分析经颅多普勒发泡试验阳性与病程、梗死类型、家族史、梗死部位等存在相关性,差异有统计学意义（P<0.05）。logistic回归分析显示病程、梗死类型、家族史、梗死部位都为导致经颅多普勒发泡试验阳性的重要因素,差异有统计学意义（P<0.05）。结论脑梗死患者多伴有经颅多普勒发泡试验阳性,经颅多普勒发泡试验阳性与脑梗死病理特征存在相关性,为此在隐源性脑梗死的病因筛查中,需要积极使用经颅多普勒发泡试验进行检查。

关键词: 脑梗死, 经颅多普勒发泡试验, 病理特征, 相关性, 反常性栓塞量表, 卵圆孔未闭

Abstract: Objective To explore and analysis the correlation between positive control-enhanced tran-scranial doppler (c-TCD) test and pathological features of cerebral infarction. Methods From January 2020 to April 2022, 137 patients with cerebral infarction were selected for diagnosis and treatment in the Third Affiliated Hospital of Soochow University. All patients were examined by c-TCD test, according to the determination of the microbubble signal, there were 73 cases in the positive foaming group and 64 cases in the negative foaming group.The general data, blood routine data, pathological characteristics of all patients were investigated and correlation analysis was carried out. Results In the 137 patients, there were 73 cases were positive by transcranial Doppler foaming test (positive group), accounted for 53.3%, included 40 cases of grade I, 20 cases of grade II, and 13 cases of grade III. There was no significant difference in age, body mass index, years of education and blood pressure compared between the positive group and the negative group (P>0.05). There was no significant difference in blood glucose, D-dimer, fibrinogen, platelet count and hemoglobin compared between the two groups (P>0.05). The score of the scale of paradoxical embolism (RoPE) in the positive group was significantly lower than that in the negative group, and the incidence of disease duration and family history were significantly higher than that of the foaming negative group, the differencewassignificant(P<0.05). The difference was significant in the type and location of infarction between the two groups (P<0.05). In the 73 patients, the Spearman correlation analysis showed that the positive transcranial Doppler foaming test was correlated with the course of disease, infarct type, family history, and infarct location (P<0.05). Logistic regression analysis showed that the course of disease, infarct type, family history, and infarct location were all important factors leaded to a positive transcranial Doppler bubble test (P<0.05). Conclusion Patients with cerebral infarction are often accompanied by positive transcranial Doppler foaming test, and the positive transcranial Doppler foaming test is correlated with the pathological characteristics of cerebral infarction. Therefore, in the screening of the etiology of cryptogenic cerebral infarction, Active use of transcranial Doppler foam testing is required.

Key words: Cerebral infarction, c-TCD, pathological features, correlation, paradoxical embolism scale, patent foramen ovale

中图分类号:

R743

贺烨, 何英*. 经颅多普勒发泡试验阳性与脑梗死病理特征的相关性分析[J]. 中华养生保健, 2022, 40(19): 5-8.

HE Ye, He Ying. Correlation analysis between positive transcranial Doppler foaming test and pathological features of cerebral infarction[J]. ZHONGHUA YANGSHENG BAOJIAN, 2022, 40(19): 5-8.

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