Abstract: Objective To evaluate the value of combined detection of serum carbohydrate antigen 153 (CA153), carbohydrate antigen 125 (CA125) and carcinoembryonic antigen (CEA) in the diagnosis and prognosis of breast cancer (BC). Methods The clinical case data of 112 BC patients (breast cancer group) who were initially treated in Yantai Laiyang Central Hospital from January 2017 to June 2019, and 50 patients with benign breast lesions (benign control group) who visited the hospital during the same period were collected.Serum CA153,CA125 and CEA were detected in both groups. Results The serum levels of CA153,CA125 and CEA in breast cancer group were higher than those in benign control group,and the difference was statistically significant(P<0.05).The sensitivity,accuracy and negative predictive value of serum CA153 and CA125 combined with CEA in the diagnosis of BC were higher than those of single serum markers, and the differences were statistically significant (P<0.05).The 5-year no-event incidence rate in the BC serum CA153, CA125, and CEA high-level expression group was lower than that of the low-level expression group, which was statistically significant (P<0.05). Conclusion CA153,CA125 combined with CEA can improve the diagnostic value of BC, and the long-term prognosis of patients with high expression of CA153 and CA125 is worse.

Key words: breast cancer, carbohydrate antigen 153, carbohydrate antigen 125, carcinoembryonic antigen, diagnosis, prognosis